Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

Ming Li; Yi Wang; Xue Bin Zheng; Masashi Ikeda; Nakao Iwata; Xiong Jian Luo; Siow Ann Chong; Jimmy Lee; Marcella Rietschel; Fengyu Zhang; Bertram Müller-Myhsok; Sven Cichon; Daniel R. Weinberger; Manuel Mattheisen; Thomas G. Schulze; Nicholas G. Martin; Philip B. Mitchell; Peter R. Schofield; Jian Jun Liu; Bing Su

doi:10.1016/j.schres.2012.10.008

Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

Ming Li, Yi Wang, Xue Bin Zheng, Masashi Ikeda, Nakao Iwata, Xiong Jian Luo, Siow Ann Chong, Jimmy Lee, Marcella Rietschel, Fengyu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R. Weinberger, Manuel Mattheisen, Thomas G. Schulze, Nicholas G. Martin, Philip B. Mitchell, Peter R. Schofield, Jian Jun Liu, Bing Su

Psychiatry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10^-4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

Original language	English
Pages (from-to)	200-205
Number of pages	6
Journal	Schizophrenia Research
Volume	142
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.10.008
Publication status	Published - 12-2012

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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Li, M., Wang, Y., Zheng, X. B., Ikeda, M., Iwata, N., Luo, X. J., Chong, S. A., Lee, J., Rietschel, M., Zhang, F., Müller-Myhsok, B., Cichon, S., Weinberger, D. R., Mattheisen, M., Schulze, T. G., Martin, N. G., Mitchell, P. B., Schofield, P. R., Liu, J. J., & Su, B. (2012). Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. Schizophrenia Research, 142(1-3), 200-205. https://doi.org/10.1016/j.schres.2012.10.008

Li, Ming ; Wang, Yi ; Zheng, Xue Bin ; Ikeda, Masashi ; Iwata, Nakao ; Luo, Xiong Jian ; Chong, Siow Ann ; Lee, Jimmy ; Rietschel, Marcella ; Zhang, Fengyu ; Müller-Myhsok, Bertram ; Cichon, Sven ; Weinberger, Daniel R. ; Mattheisen, Manuel ; Schulze, Thomas G. ; Martin, Nicholas G. ; Mitchell, Philip B. ; Schofield, Peter R. ; Liu, Jian Jun ; Su, Bing. / Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. In: Schizophrenia Research. 2012 ; Vol. 142, No. 1-3. pp. 200-205.

@article{9832f71cc4f7490480c62b094a2a6ae6,

title = "Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility",

abstract = "Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10-4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.",

author = "Ming Li and Yi Wang and Zheng, {Xue Bin} and Masashi Ikeda and Nakao Iwata and Luo, {Xiong Jian} and Chong, {Siow Ann} and Jimmy Lee and Marcella Rietschel and Fengyu Zhang and Bertram M{\"u}ller-Myhsok and Sven Cichon and Weinberger, {Daniel R.} and Manuel Mattheisen and Schulze, {Thomas G.} and Martin, {Nicholas G.} and Mitchell, {Philip B.} and Schofield, {Peter R.} and Liu, {Jian Jun} and Bing Su",

note = "Funding Information: This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (31237068), the National Medical Research Council Translational and Clinical Research Flagship Program (grant number, NMRC/TCR/003/2008), the German Federal Ministry of Education and Research (BMBF), within the context of the National Genome Research Network (NGFN), and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to S.C, grant 01GS08147 to M.R.). Recruitment of the Australian BDP sample was supported by the Australian NHMRC program (grant number 510135). ",

year = "2012",

month = dec,

doi = "10.1016/j.schres.2012.10.008",

language = "English",

volume = "142",

pages = "200--205",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "1-3",

}

Li, M, Wang, Y, Zheng, XB, Ikeda, M , Iwata, N, Luo, XJ, Chong, SA, Lee, J, Rietschel, M, Zhang, F, Müller-Myhsok, B, Cichon, S, Weinberger, DR, Mattheisen, M, Schulze, TG, Martin, NG, Mitchell, PB, Schofield, PR, Liu, JJ & Su, B 2012, 'Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility', Schizophrenia Research, vol. 142, no. 1-3, pp. 200-205. https://doi.org/10.1016/j.schres.2012.10.008

Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. / Li, Ming; Wang, Yi; Zheng, Xue Bin; Ikeda, Masashi ; Iwata, Nakao; Luo, Xiong Jian; Chong, Siow Ann; Lee, Jimmy; Rietschel, Marcella; Zhang, Fengyu; Müller-Myhsok, Bertram; Cichon, Sven; Weinberger, Daniel R.; Mattheisen, Manuel; Schulze, Thomas G.; Martin, Nicholas G.; Mitchell, Philip B.; Schofield, Peter R.; Liu, Jian Jun; Su, Bing.

In: Schizophrenia Research, Vol. 142, No. 1-3, 12.2012, p. 200-205.

Research output: Contribution to journal › Article › peer-review

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AU - Li, Ming

AU - Wang, Yi

AU - Zheng, Xue Bin

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Luo, Xiong Jian

AU - Chong, Siow Ann

AU - Lee, Jimmy

AU - Rietschel, Marcella

AU - Zhang, Fengyu

AU - Müller-Myhsok, Bertram

AU - Cichon, Sven

AU - Weinberger, Daniel R.

AU - Mattheisen, Manuel

AU - Schulze, Thomas G.

AU - Martin, Nicholas G.

AU - Mitchell, Philip B.

AU - Schofield, Peter R.

AU - Liu, Jian Jun

AU - Su, Bing

N1 - Funding Information: This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (31237068), the National Medical Research Council Translational and Clinical Research Flagship Program (grant number, NMRC/TCR/003/2008), the German Federal Ministry of Education and Research (BMBF), within the context of the National Genome Research Network (NGFN), and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to S.C, grant 01GS08147 to M.R.). Recruitment of the Australian BDP sample was supported by the Australian NHMRC program (grant number 510135).

PY - 2012/12

Y1 - 2012/12

N2 - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10-4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

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