Abstract
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10 -4 , N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 200-205 |
| Number of pages | 6 |
| Journal | Schizophrenia Research |
| Volume | 142 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 01-12-2012 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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}
Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. / Li, Ming; Wang, Yi; Zheng, Xue Bin; Ikeda, Masashi; Iwata, Nakao; Luo, Xiong Jian; Chong, Siow Ann; Lee, Jimmy; Rietschel, Marcella; Zhang, Fengyu; Müller-Myhsok, Bertram; Cichon, Sven; Weinberger, Daniel R.; Mattheisen, Manuel; Schulze, Thomas G.; Martin, Nicholas G.; Mitchell, Philip B.; Schofield, Peter R.; Liu, Jian Jun; Su, Bing.
In: Schizophrenia Research, Vol. 142, No. 1-3, 01.12.2012, p. 200-205.Research output: Contribution to journal › Article
TY - JOUR
T1 - Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
AU - Li, Ming
AU - Wang, Yi
AU - Zheng, Xue Bin
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Luo, Xiong Jian
AU - Chong, Siow Ann
AU - Lee, Jimmy
AU - Rietschel, Marcella
AU - Zhang, Fengyu
AU - Müller-Myhsok, Bertram
AU - Cichon, Sven
AU - Weinberger, Daniel R.
AU - Mattheisen, Manuel
AU - Schulze, Thomas G.
AU - Martin, Nicholas G.
AU - Mitchell, Philip B.
AU - Schofield, Peter R.
AU - Liu, Jian Jun
AU - Su, Bing
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10 -4 , N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
AB - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10 -4 , N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=84869889851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869889851&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2012.10.008
DO - 10.1016/j.schres.2012.10.008
M3 - Article
VL - 142
SP - 200
EP - 205
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -