TY - JOUR
T1 - Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
AU - Li, Ming
AU - Wang, Yi
AU - Zheng, Xue Bin
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Luo, Xiong Jian
AU - Chong, Siow Ann
AU - Lee, Jimmy
AU - Rietschel, Marcella
AU - Zhang, Fengyu
AU - Müller-Myhsok, Bertram
AU - Cichon, Sven
AU - Weinberger, Daniel R.
AU - Mattheisen, Manuel
AU - Schulze, Thomas G.
AU - Martin, Nicholas G.
AU - Mitchell, Philip B.
AU - Schofield, Peter R.
AU - Liu, Jian Jun
AU - Su, Bing
N1 - Funding Information:
This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (31237068), the National Medical Research Council Translational and Clinical Research Flagship Program (grant number, NMRC/TCR/003/2008), the German Federal Ministry of Education and Research (BMBF), within the context of the National Genome Research Network (NGFN), and the Integrated Genome Research Network (IG) MooDS (grant 01GS08144 to S.C, grant 01GS08147 to M.R.). Recruitment of the Australian BDP sample was supported by the Australian NHMRC program (grant number 510135).
PY - 2012/12
Y1 - 2012/12
N2 - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10-4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
AB - Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10-4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
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U2 - 10.1016/j.schres.2012.10.008
DO - 10.1016/j.schres.2012.10.008
M3 - Article
C2 - 23102693
AN - SCOPUS:84869889851
VL - 142
SP - 200
EP - 205
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -