Meta-analysis identifies common variants associated with body mass index in east Asians

Wanqing Wen, Yoon Shin Cho, Wei Zheng, Rajkumar Dorajoo, Norihiro Kato, Lu Qi, Chien Hsiun Chen, Ryan J. Delahanty, Yukinori Okada, Yasuharu Tabara, Dongfeng Gu, Dingliang Zhu, Christopher A. Haiman, Zengnan Mo, Yu Tang Gao, Seang Mei Saw, Min Jin Go, Fumihiko Takeuchi, Li Ching Chang, Yoshihiro Kokubo & 43 others Jun Liang, Mei Hao, Loic Le Marchand, Yi Zhang, Yanling Hu, Tien Yin Wong, Jirong Long, Bok Ghee Han, Michiaki Kubo, Ken Yamamoto, Mei Hsin Su, Tetsuro Miki, Brian E. Henderson, Huaidong Song, Aihua Tan, Jiang He, Daniel P.K. Ng, Qiuyin Cai, Tatsuhiko Tsunoda, Fuu Jen Tsai, Naoharu Iwai, Gary K. Chen, Jiajun Shi, Jianfeng Xu, Xueling Sim, Yong Bing Xiang, Shiro Maeda, Rick T.H. Ong, Chun Li, Yusuke Nakamura, Tin Aung, Naoyuki Kamatani, Jian Jun Liu, Wei Lu, Mitsuhiro Yokota, Mark Seielstad, Cathy S.J. Fann, Jer Yuarn Wu, Jong Young Lee, Frank B. Hu, Toshihiro Tanaka, E. Shyong Tai, Xiao Ou Shu

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Abstract

Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 - 10 g8), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 - 10 g7. Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalNature Genetics
Volume44
Issue number3
DOIs
Publication statusPublished - 01-03-2012

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Meta-Analysis
Body Mass Index
Obesity
Genome
Genetic Loci
Genome-Wide Association Study
Brain-Derived Neurotrophic Factor
Computer Simulation
Population
Genes
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Wen, W., Cho, Y. S., Zheng, W., Dorajoo, R., Kato, N., Qi, L., ... Shu, X. O. (2012). Meta-analysis identifies common variants associated with body mass index in east Asians. Nature Genetics, 44(3), 307-311. https://doi.org/10.1038/ng.1087
Wen, Wanqing ; Cho, Yoon Shin ; Zheng, Wei ; Dorajoo, Rajkumar ; Kato, Norihiro ; Qi, Lu ; Chen, Chien Hsiun ; Delahanty, Ryan J. ; Okada, Yukinori ; Tabara, Yasuharu ; Gu, Dongfeng ; Zhu, Dingliang ; Haiman, Christopher A. ; Mo, Zengnan ; Gao, Yu Tang ; Saw, Seang Mei ; Go, Min Jin ; Takeuchi, Fumihiko ; Chang, Li Ching ; Kokubo, Yoshihiro ; Liang, Jun ; Hao, Mei ; Le Marchand, Loic ; Zhang, Yi ; Hu, Yanling ; Wong, Tien Yin ; Long, Jirong ; Han, Bok Ghee ; Kubo, Michiaki ; Yamamoto, Ken ; Su, Mei Hsin ; Miki, Tetsuro ; Henderson, Brian E. ; Song, Huaidong ; Tan, Aihua ; He, Jiang ; Ng, Daniel P.K. ; Cai, Qiuyin ; Tsunoda, Tatsuhiko ; Tsai, Fuu Jen ; Iwai, Naoharu ; Chen, Gary K. ; Shi, Jiajun ; Xu, Jianfeng ; Sim, Xueling ; Xiang, Yong Bing ; Maeda, Shiro ; Ong, Rick T.H. ; Li, Chun ; Nakamura, Yusuke ; Aung, Tin ; Kamatani, Naoyuki ; Liu, Jian Jun ; Lu, Wei ; Yokota, Mitsuhiro ; Seielstad, Mark ; Fann, Cathy S.J. ; Wu, Jer Yuarn ; Lee, Jong Young ; Hu, Frank B. ; Tanaka, Toshihiro ; Tai, E. Shyong ; Shu, Xiao Ou. / Meta-analysis identifies common variants associated with body mass index in east Asians. In: Nature Genetics. 2012 ; Vol. 44, No. 3. pp. 307-311.
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Wen, W, Cho, YS, Zheng, W, Dorajoo, R, Kato, N, Qi, L, Chen, CH, Delahanty, RJ, Okada, Y, Tabara, Y, Gu, D, Zhu, D, Haiman, CA, Mo, Z, Gao, YT, Saw, SM, Go, MJ, Takeuchi, F, Chang, LC, Kokubo, Y, Liang, J, Hao, M, Le Marchand, L, Zhang, Y, Hu, Y, Wong, TY, Long, J, Han, BG, Kubo, M, Yamamoto, K, Su, MH, Miki, T, Henderson, BE, Song, H, Tan, A, He, J, Ng, DPK, Cai, Q, Tsunoda, T, Tsai, FJ, Iwai, N, Chen, GK, Shi, J, Xu, J, Sim, X, Xiang, YB, Maeda, S, Ong, RTH, Li, C, Nakamura, Y, Aung, T, Kamatani, N, Liu, JJ, Lu, W, Yokota, M, Seielstad, M, Fann, CSJ, Wu, JY, Lee, JY, Hu, FB, Tanaka, T, Tai, ES & Shu, XO 2012, 'Meta-analysis identifies common variants associated with body mass index in east Asians', Nature Genetics, vol. 44, no. 3, pp. 307-311. https://doi.org/10.1038/ng.1087

Meta-analysis identifies common variants associated with body mass index in east Asians. / Wen, Wanqing; Cho, Yoon Shin; Zheng, Wei; Dorajoo, Rajkumar; Kato, Norihiro; Qi, Lu; Chen, Chien Hsiun; Delahanty, Ryan J.; Okada, Yukinori; Tabara, Yasuharu; Gu, Dongfeng; Zhu, Dingliang; Haiman, Christopher A.; Mo, Zengnan; Gao, Yu Tang; Saw, Seang Mei; Go, Min Jin; Takeuchi, Fumihiko; Chang, Li Ching; Kokubo, Yoshihiro; Liang, Jun; Hao, Mei; Le Marchand, Loic; Zhang, Yi; Hu, Yanling; Wong, Tien Yin; Long, Jirong; Han, Bok Ghee; Kubo, Michiaki; Yamamoto, Ken; Su, Mei Hsin; Miki, Tetsuro; Henderson, Brian E.; Song, Huaidong; Tan, Aihua; He, Jiang; Ng, Daniel P.K.; Cai, Qiuyin; Tsunoda, Tatsuhiko; Tsai, Fuu Jen; Iwai, Naoharu; Chen, Gary K.; Shi, Jiajun; Xu, Jianfeng; Sim, Xueling; Xiang, Yong Bing; Maeda, Shiro; Ong, Rick T.H.; Li, Chun; Nakamura, Yusuke; Aung, Tin; Kamatani, Naoyuki; Liu, Jian Jun; Lu, Wei; Yokota, Mitsuhiro; Seielstad, Mark; Fann, Cathy S.J.; Wu, Jer Yuarn; Lee, Jong Young; Hu, Frank B.; Tanaka, Toshihiro; Tai, E. Shyong; Shu, Xiao Ou.

In: Nature Genetics, Vol. 44, No. 3, 01.03.2012, p. 307-311.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Meta-analysis identifies common variants associated with body mass index in east Asians

AU - Wen, Wanqing

AU - Cho, Yoon Shin

AU - Zheng, Wei

AU - Dorajoo, Rajkumar

AU - Kato, Norihiro

AU - Qi, Lu

AU - Chen, Chien Hsiun

AU - Delahanty, Ryan J.

AU - Okada, Yukinori

AU - Tabara, Yasuharu

AU - Gu, Dongfeng

AU - Zhu, Dingliang

AU - Haiman, Christopher A.

AU - Mo, Zengnan

AU - Gao, Yu Tang

AU - Saw, Seang Mei

AU - Go, Min Jin

AU - Takeuchi, Fumihiko

AU - Chang, Li Ching

AU - Kokubo, Yoshihiro

AU - Liang, Jun

AU - Hao, Mei

AU - Le Marchand, Loic

AU - Zhang, Yi

AU - Hu, Yanling

AU - Wong, Tien Yin

AU - Long, Jirong

AU - Han, Bok Ghee

AU - Kubo, Michiaki

AU - Yamamoto, Ken

AU - Su, Mei Hsin

AU - Miki, Tetsuro

AU - Henderson, Brian E.

AU - Song, Huaidong

AU - Tan, Aihua

AU - He, Jiang

AU - Ng, Daniel P.K.

AU - Cai, Qiuyin

AU - Tsunoda, Tatsuhiko

AU - Tsai, Fuu Jen

AU - Iwai, Naoharu

AU - Chen, Gary K.

AU - Shi, Jiajun

AU - Xu, Jianfeng

AU - Sim, Xueling

AU - Xiang, Yong Bing

AU - Maeda, Shiro

AU - Ong, Rick T.H.

AU - Li, Chun

AU - Nakamura, Yusuke

AU - Aung, Tin

AU - Kamatani, Naoyuki

AU - Liu, Jian Jun

AU - Lu, Wei

AU - Yokota, Mitsuhiro

AU - Seielstad, Mark

AU - Fann, Cathy S.J.

AU - Wu, Jer Yuarn

AU - Lee, Jong Young

AU - Hu, Frank B.

AU - Tanaka, Toshihiro

AU - Tai, E. Shyong

AU - Shu, Xiao Ou

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 - 10 g8), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 - 10 g7. Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.

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