Meta-analysis identifies common variants associated with body mass index in east Asians

Wanqing Wen, Yoon Shin Cho, Wei Zheng, Rajkumar Dorajoo, Norihiro Kato, Lu Qi, Chien Hsiun Chen, Ryan J. Delahanty, Yukinori Okada, Yasuharu Tabara, Dongfeng Gu, Dingliang Zhu, Christopher A. Haiman, Zengnan Mo, Yu Tang Gao, Seang Mei Saw, Min Jin Go, Fumihiko Takeuchi, Li Ching Chang, Yoshihiro KokuboJun Liang, Mei Hao, Loic Le Marchand, Yi Zhang, Yanling Hu, Tien Yin Wong, Jirong Long, Bok Ghee Han, Michiaki Kubo, Ken Yamamoto, Mei Hsin Su, Tetsuro Miki, Brian E. Henderson, Huaidong Song, Aihua Tan, Jiang He, Daniel P.K. Ng, Qiuyin Cai, Tatsuhiko Tsunoda, Fuu Jen Tsai, Naoharu Iwai, Gary K. Chen, Jiajun Shi, Jianfeng Xu, Xueling Sim, Yong Bing Xiang, Shiro Maeda, Rick T.H. Ong, Chun Li, Yusuke Nakamura, Tin Aung, Naoyuki Kamatani, Jian Jun Liu, Wei Lu, Mitsuhiro Yokota, Mark Seielstad, Cathy S.J. Fann, Jer Yuarn Wu, Jong Young Lee, Frank B. Hu, Toshihiro Tanaka, E. Shyong Tai, Xiao Ou Shu

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243 Citations (Scopus)

Abstract

Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 - 10 g8), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 - 10 g7. Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalNature Genetics
Volume44
Issue number3
DOIs
Publication statusPublished - 03-2012

All Science Journal Classification (ASJC) codes

  • Genetics

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    Wen, W., Cho, Y. S., Zheng, W., Dorajoo, R., Kato, N., Qi, L., Chen, C. H., Delahanty, R. J., Okada, Y., Tabara, Y., Gu, D., Zhu, D., Haiman, C. A., Mo, Z., Gao, Y. T., Saw, S. M., Go, M. J., Takeuchi, F., Chang, L. C., ... Shu, X. O. (2012). Meta-analysis identifies common variants associated with body mass index in east Asians. Nature Genetics, 44(3), 307-311. https://doi.org/10.1038/ng.1087