Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

Yukinori Okada, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Takahisa Kawaguchi, Eli A. Stahl, Fina A.S. Kurreeman, Nao Nishida, Hiroko Ohmiya, Keiko Myouzen, Meiko Takahashi, Tetsuji Sawada, Yuichi Nishioka, Masao Yukioka, Tsukasa Matsubara, Shigeyuki Wakitani, Ryota Teshima, Shigeto Tohma & 31 others Kiyoshi Takasugi, Kota Shimada, Akira Murasawa, Shigeru Honjo, Keitaro Matsuo, Hideo Tanaka, Kazuo Tajima, Taku Suzuki, Takuji Iwamoto, Yoshiya Kawamura, Hisashi Tanii, Yuji Okazaki, Tsukasa Sasaki, Peter K. Gregersen, Leonid Padyukov, Jane Worthington, Katherine A. Siminovitch, Mark Lathrop, Atsuo Taniguchi, Atsushi Takahashi, Katsushi Tokunaga, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Tsuneyo Mimori, Robert M. Plenge, Hisashi Yamanaka, Shigeki Momohara, Ryo Yamada, Fumihiko Matsuda, Kazuhiko Yamamoto

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10 -8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves′ disease (P = 3.5 × 10 -4 and 2.9 × 10 -4, respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalNature Genetics
Volume44
Issue number5
DOIs
Publication statusPublished - 01-05-2012

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Meta-Analysis
Rheumatoid Arthritis
Population
Genome-Wide Association Study
Graves Disease
Systemic Lupus Erythematosus
Autoimmune Diseases
Inflammation

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Okada, Y., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., Suzuki, A., ... Yamamoto, K. (2012). Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature Genetics, 44(5), 511-516. https://doi.org/10.1038/ng.2231
Okada, Yukinori ; Terao, Chikashi ; Ikari, Katsunori ; Kochi, Yuta ; Ohmura, Koichiro ; Suzuki, Akari ; Kawaguchi, Takahisa ; Stahl, Eli A. ; Kurreeman, Fina A.S. ; Nishida, Nao ; Ohmiya, Hiroko ; Myouzen, Keiko ; Takahashi, Meiko ; Sawada, Tetsuji ; Nishioka, Yuichi ; Yukioka, Masao ; Matsubara, Tsukasa ; Wakitani, Shigeyuki ; Teshima, Ryota ; Tohma, Shigeto ; Takasugi, Kiyoshi ; Shimada, Kota ; Murasawa, Akira ; Honjo, Shigeru ; Matsuo, Keitaro ; Tanaka, Hideo ; Tajima, Kazuo ; Suzuki, Taku ; Iwamoto, Takuji ; Kawamura, Yoshiya ; Tanii, Hisashi ; Okazaki, Yuji ; Sasaki, Tsukasa ; Gregersen, Peter K. ; Padyukov, Leonid ; Worthington, Jane ; Siminovitch, Katherine A. ; Lathrop, Mark ; Taniguchi, Atsuo ; Takahashi, Atsushi ; Tokunaga, Katsushi ; Kubo, Michiaki ; Nakamura, Yusuke ; Kamatani, Naoyuki ; Mimori, Tsuneyo ; Plenge, Robert M. ; Yamanaka, Hisashi ; Momohara, Shigeki ; Yamada, Ryo ; Matsuda, Fumihiko ; Yamamoto, Kazuhiko. / Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. In: Nature Genetics. 2012 ; Vol. 44, No. 5. pp. 511-516.
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abstract = "Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10 -8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves′ disease (P = 3.5 × 10 -4 and 2.9 × 10 -4, respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.",
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Okada, Y, Terao, C, Ikari, K, Kochi, Y, Ohmura, K, Suzuki, A, Kawaguchi, T, Stahl, EA, Kurreeman, FAS, Nishida, N, Ohmiya, H, Myouzen, K, Takahashi, M, Sawada, T, Nishioka, Y, Yukioka, M, Matsubara, T, Wakitani, S, Teshima, R, Tohma, S, Takasugi, K, Shimada, K, Murasawa, A, Honjo, S, Matsuo, K, Tanaka, H, Tajima, K, Suzuki, T, Iwamoto, T, Kawamura, Y, Tanii, H, Okazaki, Y, Sasaki, T, Gregersen, PK, Padyukov, L, Worthington, J, Siminovitch, KA, Lathrop, M, Taniguchi, A, Takahashi, A, Tokunaga, K, Kubo, M, Nakamura, Y, Kamatani, N, Mimori, T, Plenge, RM, Yamanaka, H, Momohara, S, Yamada, R, Matsuda, F & Yamamoto, K 2012, 'Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population', Nature Genetics, vol. 44, no. 5, pp. 511-516. https://doi.org/10.1038/ng.2231

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. / Okada, Yukinori; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Kawaguchi, Takahisa; Stahl, Eli A.; Kurreeman, Fina A.S.; Nishida, Nao; Ohmiya, Hiroko; Myouzen, Keiko; Takahashi, Meiko; Sawada, Tetsuji; Nishioka, Yuichi; Yukioka, Masao; Matsubara, Tsukasa; Wakitani, Shigeyuki; Teshima, Ryota; Tohma, Shigeto; Takasugi, Kiyoshi; Shimada, Kota; Murasawa, Akira; Honjo, Shigeru; Matsuo, Keitaro; Tanaka, Hideo; Tajima, Kazuo; Suzuki, Taku; Iwamoto, Takuji; Kawamura, Yoshiya; Tanii, Hisashi; Okazaki, Yuji; Sasaki, Tsukasa; Gregersen, Peter K.; Padyukov, Leonid; Worthington, Jane; Siminovitch, Katherine A.; Lathrop, Mark; Taniguchi, Atsuo; Takahashi, Atsushi; Tokunaga, Katsushi; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Mimori, Tsuneyo; Plenge, Robert M.; Yamanaka, Hisashi; Momohara, Shigeki; Yamada, Ryo; Matsuda, Fumihiko; Yamamoto, Kazuhiko.

In: Nature Genetics, Vol. 44, No. 5, 01.05.2012, p. 511-516.

Research output: Contribution to journalArticle

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T1 - Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

AU - Okada, Yukinori

AU - Terao, Chikashi

AU - Ikari, Katsunori

AU - Kochi, Yuta

AU - Ohmura, Koichiro

AU - Suzuki, Akari

AU - Kawaguchi, Takahisa

AU - Stahl, Eli A.

AU - Kurreeman, Fina A.S.

AU - Nishida, Nao

AU - Ohmiya, Hiroko

AU - Myouzen, Keiko

AU - Takahashi, Meiko

AU - Sawada, Tetsuji

AU - Nishioka, Yuichi

AU - Yukioka, Masao

AU - Matsubara, Tsukasa

AU - Wakitani, Shigeyuki

AU - Teshima, Ryota

AU - Tohma, Shigeto

AU - Takasugi, Kiyoshi

AU - Shimada, Kota

AU - Murasawa, Akira

AU - Honjo, Shigeru

AU - Matsuo, Keitaro

AU - Tanaka, Hideo

AU - Tajima, Kazuo

AU - Suzuki, Taku

AU - Iwamoto, Takuji

AU - Kawamura, Yoshiya

AU - Tanii, Hisashi

AU - Okazaki, Yuji

AU - Sasaki, Tsukasa

AU - Gregersen, Peter K.

AU - Padyukov, Leonid

AU - Worthington, Jane

AU - Siminovitch, Katherine A.

AU - Lathrop, Mark

AU - Taniguchi, Atsuo

AU - Takahashi, Atsushi

AU - Tokunaga, Katsushi

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Kamatani, Naoyuki

AU - Mimori, Tsuneyo

AU - Plenge, Robert M.

AU - Yamanaka, Hisashi

AU - Momohara, Shigeki

AU - Yamada, Ryo

AU - Matsuda, Fumihiko

AU - Yamamoto, Kazuhiko

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10 -8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves′ disease (P = 3.5 × 10 -4 and 2.9 × 10 -4, respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.

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