Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Hiroki Ueno, Kazumi Norose, Teppei Kamimura, Keichiro Mihara, Fumiyuki Yamasaki, Kenji Hikosaka, Vishwa J. Amatya, Yukio Takeshima, Kaoru Kurisu, Hirofumi Maruyama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

Original languageEnglish
Pages (from-to)1157-1162
Number of pages6
JournalInternal Medicine
Issue number8
Publication statusPublished - 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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