Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Hiroki Ueno; Kazumi Norose; Teppei Kamimura; Keichiro Mihara; Fumiyuki Yamasaki; Kenji Hikosaka; Vishwa J. Amatya; Yukio Takeshima; Kaoru Kurisu; Hirofumi Maruyama

doi:10.2169/internalmedicine.1156-18

Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Hiroki Ueno, Kazumi Norose, Teppei Kamimura, Keichiro Mihara, Fumiyuki Yamasaki, Kenji Hikosaka, Vishwa J. Amatya, Yukio Takeshima, Kaoru Kurisu, Hirofumi Maruyama

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.¹⁸F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and²⁰¹Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

Original language	English
Pages (from-to)	1157-1162
Number of pages	6
Journal	Internal Medicine
Volume	58
Issue number	8
DOIs	https://doi.org/10.2169/internalmedicine.1156-18
Publication status	Published - 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.1156-18

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title = "Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”",

abstract = "We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.",

keywords = "Cerebral toxoplasmosis, F-FDG PET, MRI, Malignant lymphoma, Target sign, Tl-SPECT",

author = "Hiroki Ueno and Kazumi Norose and Teppei Kamimura and Keichiro Mihara and Fumiyuki Yamasaki and Kenji Hikosaka and Amatya, {Vishwa J.} and Yukio Takeshima and Kaoru Kurisu and Hirofumi Maruyama",

note = "Publisher Copyright: {\textcopyright} 2019 The Japanese Society of Internal Medicine.",

year = "2019",

doi = "10.2169/internalmedicine.1156-18",

language = "English",

volume = "58",

pages = "1157--1162",

journal = "Internal Medicine",

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publisher = "Japanese Society of Internal Medicine",

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TY - JOUR

T1 - Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

AU - Ueno, Hiroki

AU - Norose, Kazumi

AU - Kamimura, Teppei

AU - Mihara, Keichiro

AU - Yamasaki, Fumiyuki

AU - Hikosaka, Kenji

AU - Amatya, Vishwa J.

AU - Takeshima, Yukio

AU - Kurisu, Kaoru

AU - Maruyama, Hirofumi

PY - 2019

Y1 - 2019

N2 - We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

AB - We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

KW - Cerebral toxoplasmosis

KW - F-FDG PET

KW - MRI

KW - Malignant lymphoma

KW - Target sign

KW - Tl-SPECT

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DO - 10.2169/internalmedicine.1156-18

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SN - 0918-2918

VL - 58

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EP - 1162

JO - Internal Medicine

JF - Internal Medicine

IS - 8

ER -

Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Abstract

All Science Journal Classification (ASJC) codes

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