Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Hiroki Ueno; Kazumi Norose; Teppei Kamimura; Keichiro Mihara; Fumiyuki Yamasaki; Kenji Hikosaka; Vishwa J. Amatya; Yukio Takeshima; Kaoru Kurisu; Hirofumi Maruyama

doi:10.2169/internalmedicine.1156-18

Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Hiroki Ueno
, Kazumi Norose
, Teppei Kamimura
, Keichiro Mihara
, Fumiyuki Yamasaki
, Kenji Hikosaka
, Vishwa J. Amatya
, Yukio Takeshima
, Kaoru Kurisu
, Hirofumi Maruyama

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.¹⁸F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and²⁰¹Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

Original language	English
Pages (from-to)	1157-1162
Number of pages	6
Journal	Internal Medicine
Volume	58
Issue number	8
DOIs	https://doi.org/10.2169/internalmedicine.1156-18
Publication status	Published - 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.1156-18

Cite this

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title = "Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”",

abstract = "We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.",

keywords = "Cerebral toxoplasmosis, F-FDG PET, MRI, Malignant lymphoma, Target sign, Tl-SPECT",

author = "Hiroki Ueno and Kazumi Norose and Teppei Kamimura and Keichiro Mihara and Fumiyuki Yamasaki and Kenji Hikosaka and Amatya, \{Vishwa J.\} and Yukio Takeshima and Kaoru Kurisu and Hirofumi Maruyama",

note = "Publisher Copyright: {\textcopyright} 2019 The Japanese Society of Internal Medicine.",

year = "2019",

doi = "10.2169/internalmedicine.1156-18",

language = "English",

volume = "58",

pages = "1157--1162",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

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}

TY - JOUR

T1 - Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

AU - Ueno, Hiroki

AU - Norose, Kazumi

AU - Kamimura, Teppei

AU - Mihara, Keichiro

AU - Yamasaki, Fumiyuki

AU - Hikosaka, Kenji

AU - Amatya, Vishwa J.

AU - Takeshima, Yukio

AU - Kurisu, Kaoru

AU - Maruyama, Hirofumi

PY - 2019

Y1 - 2019

N2 - We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

AB - We herein report the case of a 60-year-old man with a “target sign” in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis.18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

KW - Cerebral toxoplasmosis

KW - F-FDG PET

KW - MRI

KW - Malignant lymphoma

KW - Target sign

KW - Tl-SPECT

UR - https://www.scopus.com/pages/publications/85064853482

UR - https://www.scopus.com/pages/publications/85064853482#tab=citedBy

U2 - 10.2169/internalmedicine.1156-18

DO - 10.2169/internalmedicine.1156-18

M3 - Article

C2 - 30568116

AN - SCOPUS:85064853482

SN - 0918-2918

VL - 58

SP - 1157

EP - 1162

JO - Internal Medicine

JF - Internal Medicine

IS - 8

ER -

Metastatic malignant lymphoma mimicking cerebral toxoplasmosis with the “target sign”

Abstract

All Science Journal Classification (ASJC) codes

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