TY - JOUR
T1 - Methysergide-induced precipitated withdrawal syndrome in phencyclidine-dependent rats
AU - Nabeshima, Toshitaka
AU - Ishikawa, Kazuhiro
AU - Yamaguchi, Kazumasa
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
PY - 1986/9/12
Y1 - 1986/9/12
N2 - Chronic phencyclidine (PCP) administration has been shown to produce tolerance to a number of its pharmacological actions. We have suggested that PCP interacts with the 5-HT2 receptors since it inhibits [3H]spiperone binding to 5-HT2 receptors in vitro. In the present study, we investigated whether methysergide (a 5-HT2 receptor blocker) induces the precipitated withdrawal syndrome in PCP-tolerant rats. The body weight of the rats in the abrupt and precipitated withdrawal groups was significantly lower 5 days and 1-5 days after withdrawal, respectively, than that in the control group. Furthermore, other typical precipitated abstinence syndrome characteristics such as jumping, wet-dog shake and ptosis were also observed in the precipitated withdrawal group. These results suggest that PCP produces its behavioral effects via an agonistic interaction with 5-HT2 receptor sites and that our method may be very useful for the development of a rat model for studying physical dependence on PCP.
AB - Chronic phencyclidine (PCP) administration has been shown to produce tolerance to a number of its pharmacological actions. We have suggested that PCP interacts with the 5-HT2 receptors since it inhibits [3H]spiperone binding to 5-HT2 receptors in vitro. In the present study, we investigated whether methysergide (a 5-HT2 receptor blocker) induces the precipitated withdrawal syndrome in PCP-tolerant rats. The body weight of the rats in the abrupt and precipitated withdrawal groups was significantly lower 5 days and 1-5 days after withdrawal, respectively, than that in the control group. Furthermore, other typical precipitated abstinence syndrome characteristics such as jumping, wet-dog shake and ptosis were also observed in the precipitated withdrawal group. These results suggest that PCP produces its behavioral effects via an agonistic interaction with 5-HT2 receptor sites and that our method may be very useful for the development of a rat model for studying physical dependence on PCP.
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U2 - 10.1016/0304-3940(86)90493-3
DO - 10.1016/0304-3940(86)90493-3
M3 - Article
C2 - 3763058
AN - SCOPUS:0022922090
SN - 0304-3940
VL - 69
SP - 275
EP - 278
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -