mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration

H. Urakubo; M. Watanabe

doi:10.1109/ICONIP.2002.1202868

mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this study, we inquire the generation mechanism of the spike-timing dependent synaptic plasticity by computer simulation. Postsynaptic Ca²⁺ concentration in a spine determines synaptic plasticity. We examine the spike timing dependence of Ca²⁺ concentration with a multi-compartment model of a hippocampal CA1 pyramidal cell. Consequently, only the Ca²⁺ concentration does not account for STDP, but the Ca²⁺ concentration filtered by mGluR-activation reproduces STDP timing window.

Original language	English
Title of host publication	ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing
Subtitle of host publication	Computational Intelligence for the E-Age
Editors	Jagath C. Rajapakse, Soo-Young Lee, Lipo Wang, Kunihiko Fukushima, Xin Yao
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1490-1494
Number of pages	5
ISBN (Electronic)	9810475241, 9789810475246
DOIs	https://doi.org/10.1109/ICONIP.2002.1202868
Publication status	Published - 2002
Externally published	Yes
Event	9th International Conference on Neural Information Processing, ICONIP 2002 - Singapore, Singapore Duration: 18-11-2002 → 22-11-2002

Publication series

Name	ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age
Volume	3

Conference

Conference	9th International Conference on Neural Information Processing, ICONIP 2002
Country/Territory	Singapore
City	Singapore
Period	18-11-02 → 22-11-02

All Science Journal Classification (ASJC) codes

Computer Networks and Communications
Information Systems
Signal Processing

Access to Document

10.1109/ICONIP.2002.1202868

Cite this

Urakubo, H., & Watanabe, M. (2002). mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration. In J. C. Rajapakse, S.-Y. Lee, L. Wang, K. Fukushima, & X. Yao (Eds.), ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age (pp. 1490-1494). Article 1202868 (ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age; Vol. 3). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICONIP.2002.1202868

Urakubo, H. ; Watanabe, M. / mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration. ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age. editor / Jagath C. Rajapakse ; Soo-Young Lee ; Lipo Wang ; Kunihiko Fukushima ; Xin Yao. Institute of Electrical and Electronics Engineers Inc., 2002. pp. 1490-1494 (ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age).

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abstract = "In this study, we inquire the generation mechanism of the spike-timing dependent synaptic plasticity by computer simulation. Postsynaptic Ca2+ concentration in a spine determines synaptic plasticity. We examine the spike timing dependence of Ca2+ concentration with a multi-compartment model of a hippocampal CA1 pyramidal cell. Consequently, only the Ca2+ concentration does not account for STDP, but the Ca2+ concentration filtered by mGluR-activation reproduces STDP timing window.",

author = "H. Urakubo and M. Watanabe",

note = "Publisher Copyright: {\textcopyright} 2002 Nanyang Technological University.; 9th International Conference on Neural Information Processing, ICONIP 2002 ; Conference date: 18-11-2002 Through 22-11-2002",

year = "2002",

doi = "10.1109/ICONIP.2002.1202868",

language = "English",

series = "ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1490--1494",

editor = "Rajapakse, {Jagath C.} and Soo-Young Lee and Lipo Wang and Kunihiko Fukushima and Xin Yao",

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Urakubo, H & Watanabe, M 2002, mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration. in JC Rajapakse, S-Y Lee, L Wang, K Fukushima & X Yao (eds), ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age., 1202868, ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age, vol. 3, Institute of Electrical and Electronics Engineers Inc., pp. 1490-1494, 9th International Conference on Neural Information Processing, ICONIP 2002, Singapore, Singapore, 18-11-02. https://doi.org/10.1109/ICONIP.2002.1202868

mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration. / Urakubo, H.; Watanabe, M.
ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age. ed. / Jagath C. Rajapakse; Soo-Young Lee; Lipo Wang; Kunihiko Fukushima; Xin Yao. Institute of Electrical and Electronics Engineers Inc., 2002. p. 1490-1494 1202868 (ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - In this study, we inquire the generation mechanism of the spike-timing dependent synaptic plasticity by computer simulation. Postsynaptic Ca2+ concentration in a spine determines synaptic plasticity. We examine the spike timing dependence of Ca2+ concentration with a multi-compartment model of a hippocampal CA1 pyramidal cell. Consequently, only the Ca2+ concentration does not account for STDP, but the Ca2+ concentration filtered by mGluR-activation reproduces STDP timing window.

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Urakubo H, Watanabe M. mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration. In Rajapakse JC, Lee SY, Wang L, Fukushima K, Yao X, editors, ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age. Institute of Electrical and Electronics Engineers Inc. 2002. p. 1490-1494. 1202868. (ICONIP 2002 - Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E-Age). doi: 10.1109/ICONIP.2002.1202868

mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration

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