MHC-restricted cell-mediated cytotoxicity in fish

Teruyuki Nakanishi, Uwe Fischer, Johannes M. Dijkstra, Mitsuru Ototake

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cytotoxic T cells taken from an individual recovering from a viral infection are capable of killing only virally infected cells which share an MHC haplotype with the host (MHC restriction). Very recently extensive allelic polymorphism of MHC class I genes has been demonstrated in both elasmobranchs and teleosts. Accordingly, we should use effector and target cells with the same MHC haplotype to study the MHC-restricted, antigen-specific cytotoxic T cell response in fish. In this symposium our recent studies on polymorphism and function of shark and rainbow trout MHC I genes were first described, followed by MHC-restricted cell-mediated cytotoxicity against virus-infected cell lines using homozygous clonal rainbow trout (C25 clone) sensitized by DNA immunization with IHNV-G or by infection with IHNV and trout cell line (RTG-2) which shares the same MHC I allele with the trout.

Original languageEnglish
Pages (from-to)1143-1146
Number of pages4
JournalFisheries Science
Volume68
DOIs
Publication statusPublished - 01-01-2002

Fingerprint

rainbow
cytotoxicity
polymorphism
trout
immunization
gene
Oncorhynchus mykiss
haplotypes
fish
T-lymphocytes
shark
antigen
teleost
cell lines
genetic polymorphism
clone
allele
virus
cells
sharks

All Science Journal Classification (ASJC) codes

  • Aquatic Science

Cite this

Nakanishi, Teruyuki ; Fischer, Uwe ; Dijkstra, Johannes M. ; Ototake, Mitsuru. / MHC-restricted cell-mediated cytotoxicity in fish. In: Fisheries Science. 2002 ; Vol. 68. pp. 1143-1146.
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MHC-restricted cell-mediated cytotoxicity in fish. / Nakanishi, Teruyuki; Fischer, Uwe; Dijkstra, Johannes M.; Ototake, Mitsuru.

In: Fisheries Science, Vol. 68, 01.01.2002, p. 1143-1146.

Research output: Contribution to journalArticle

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