Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system

Chulsoo Ahn, Alveena Syed, Fupin Hu, Jessica A. O'Hara, Jesabel I. Rivera, Yohei Doi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis showed diverse restriction patterns overall, multilocus sequence typing identified Enterobacter cloacae isolates with sequence types 93 and 171 from 2 hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin and tigecycline, and the majority, to amikacin and doxycycline. A blaKPC-carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in 3 of the isolates. Spread of blaKPC in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume80
Issue number2
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

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Enterobacter
Klebsiella pneumoniae
Plasmids
Trimethoprim Resistance
Colistin
Multilocus Sequence Typing
Enterobacter cloacae
Carbapenems
Amikacin
Doxycycline
Pulsed Field Gel Electrophoresis
Sulfamethoxazole Drug Combination Trimethoprim
Microbial Sensitivity Tests
Delivery of Health Care
carbapenemase

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Ahn, Chulsoo ; Syed, Alveena ; Hu, Fupin ; O'Hara, Jessica A. ; Rivera, Jesabel I. ; Doi, Yohei. / Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system. In: Diagnostic Microbiology and Infectious Disease. 2014 ; Vol. 80, No. 2. pp. 154-158.
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Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system. / Ahn, Chulsoo; Syed, Alveena; Hu, Fupin; O'Hara, Jessica A.; Rivera, Jesabel I.; Doi, Yohei.

In: Diagnostic Microbiology and Infectious Disease, Vol. 80, No. 2, 01.01.2014, p. 154-158.

Research output: Contribution to journalArticle

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