Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system

Chulsoo Ahn, Alveena Syed, Fupin Hu, Jessica A. O'Hara, Jesabel I. Rivera, Yohei Doi

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis showed diverse restriction patterns overall, multilocus sequence typing identified Enterobacter cloacae isolates with sequence types 93 and 171 from 2 hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin and tigecycline, and the majority, to amikacin and doxycycline. A blaKPC-carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in 3 of the isolates. Spread of blaKPC in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Issue number2
Publication statusPublished - 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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