TY - JOUR
T1 - MicroRNA-7 is associated with malignant potential and poor prognosis in human colorectal cancer
AU - Nagano, Yuka
AU - Toiyama, Yuji
AU - Okugawa, Yoshinaga
AU - Imaoka, Hiroki
AU - Fujikawa, Hiroyuki
AU - Yasuda, Hiromi
AU - Yoshiyama, Shigeyuki
AU - Hiro, Junichiro
AU - Kobayashi, Minako
AU - Ohi, Masaki
AU - Araki, Toshimitsu
AU - Inoue, Yasuhiro
AU - Mohri, Yasuhiko
AU - Kusunoki, Masato
PY - 2016/12
Y1 - 2016/12
N2 - Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. Here, we investigated the relationship between clinicopathological factors, including prognostic outcome, and miR-7 expression in CRC tissues. We analyzed miR-7 expression levels by real-time reverse transcription polymerase chain reaction in 210 colorectal tissues (196 CRCs and 14 normal mucosae from healthy volunteers). miR-7 expression levels were significantly upregulated in CRC tissues compared to normal colorectal mucosae. Elevated miR-7 expression was significantly correlated with tumour depth, venous invasion, lymphatic invasion, lymph node metastasis, and liver metastasis. High miR-7 expression was significantly associated with poor overall survival in patients with CRC (p=0.010). Moreover, miR-7 expression was an independent prognostic factor in patients with CRC (hazard ratio=1.854, 95% confidence interval=1.016-3.540; p=0.044). miR-7 acts as an oncogene in CRC and is significantly associated with tumour progression and poor prognosis.
AB - Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. Here, we investigated the relationship between clinicopathological factors, including prognostic outcome, and miR-7 expression in CRC tissues. We analyzed miR-7 expression levels by real-time reverse transcription polymerase chain reaction in 210 colorectal tissues (196 CRCs and 14 normal mucosae from healthy volunteers). miR-7 expression levels were significantly upregulated in CRC tissues compared to normal colorectal mucosae. Elevated miR-7 expression was significantly correlated with tumour depth, venous invasion, lymphatic invasion, lymph node metastasis, and liver metastasis. High miR-7 expression was significantly associated with poor overall survival in patients with CRC (p=0.010). Moreover, miR-7 expression was an independent prognostic factor in patients with CRC (hazard ratio=1.854, 95% confidence interval=1.016-3.540; p=0.044). miR-7 acts as an oncogene in CRC and is significantly associated with tumour progression and poor prognosis.
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U2 - 10.21873/anticanres.11253
DO - 10.21873/anticanres.11253
M3 - Article
C2 - 27919977
AN - SCOPUS:85002496931
SN - 0250-7005
VL - 36
SP - 6521
EP - 6526
JO - Anticancer research
JF - Anticancer research
IS - 12
ER -
