MicroRNA-7 is associated with malignant potential and poor prognosis in human colorectal cancer

Yuka Nagano, Yuji Toiyama, Yoshinaga Okugawa, Hiroki Imaoka, Hiroyuki Fujikawa, Hiromi Yasuda, Shigeyuki Yoshiyama, Junichiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. Here, we investigated the relationship between clinicopathological factors, including prognostic outcome, and miR-7 expression in CRC tissues. We analyzed miR-7 expression levels by real-time reverse transcription polymerase chain reaction in 210 colorectal tissues (196 CRCs and 14 normal mucosae from healthy volunteers). miR-7 expression levels were significantly upregulated in CRC tissues compared to normal colorectal mucosae. Elevated miR-7 expression was significantly correlated with tumour depth, venous invasion, lymphatic invasion, lymph node metastasis, and liver metastasis. High miR-7 expression was significantly associated with poor overall survival in patients with CRC (p=0.010). Moreover, miR-7 expression was an independent prognostic factor in patients with CRC (hazard ratio=1.854, 95% confidence interval=1.016-3.540; p=0.044). miR-7 acts as an oncogene in CRC and is significantly associated with tumour progression and poor prognosis.

Original languageEnglish
Pages (from-to)6521-6526
Number of pages6
JournalAnticancer research
Volume36
Issue number12
DOIs
Publication statusPublished - 12-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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