Migration activity of microglia and macrophages into rat brain

F. Imai; M. Sawada; H. Suzuki; N. Kiya; M. Hayakawa; T. Nagatsu; T. Marunouchi; T. Kanno

doi:10.1016/S0304-3940(97)00808-2

Migration activity of microglia and macrophages into rat brain

F. Imai, M. Sawada, H. Suzuki, N. Kiya, M. Hayakawa, T. Nagatsu, T. Marunouchi, T. Kanno

Neurosurgery

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We examined the entry of intra-arterially injected microglia and macrophages into the brain using a rat muscle graft model to compare their respective abilities to invade the brain parenchyma. Isolated microglia without any activation treatment entered into the brain with or without the muscle graft, while macrophages activated by phorbol 12-myristate-13-acetate (PMA) entered the brain only in the presence of the muscle graft. These results suggest that microglia have a higher affinity for the brain than macrophages.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	Neuroscience Letters
Volume	237
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(97)00808-2
Publication status	Published - 14-11-1997

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/S0304-3940(97)00808-2

Cite this

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AU - Sawada, M.

AU - Suzuki, H.

AU - Kiya, N.

AU - Hayakawa, M.

AU - Nagatsu, T.

AU - Marunouchi, T.

AU - Kanno, T.

PY - 1997/11/14

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Migration activity of microglia and macrophages into rat brain

Abstract

All Science Journal Classification (ASJC) codes

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