Migration activity of microglia and macrophages into rat brain

F. Imai, M. Sawada, H. Suzuki, N. Kiya, M. Hayakawa, T. Nagatsu, T. Marunouchi, T. Kanno

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


We examined the entry of intra-arterially injected microglia and macrophages into the brain using a rat muscle graft model to compare their respective abilities to invade the brain parenchyma. Isolated microglia without any activation treatment entered into the brain with or without the muscle graft, while macrophages activated by phorbol 12-myristate-13-acetate (PMA) entered the brain only in the presence of the muscle graft. These results suggest that microglia have a higher affinity for the brain than macrophages.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 14-11-1997

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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