Miliary tuberculosis and tuberculous peritonitis during infliximab treatment for rheumatoid arthritis

Tomoyo Oguri, Satoru Ito, Mariko Morishita, Koji Sakamoto, Masashi Kondo, Yoshinori Hasegawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A 55-year-old woman treated with infliximab for rheumatoid arthritis was admitted due to progressive ascites. A CT scan showed massive ascites, bilateral pleural effusion, disseminated granular shadows in the lung, and multiple swollen mediastinal lymph nodes. A FDG-PET/CT scan showed increases of FDG uptake in the mesentery and peritoneum, mimicking peritoneal carcinomatosis. Subsequent pleural and peritoneal fluid analysis showed elevated adenosine deaminase activity levels with no malignant cells. A right pleural biopsy specimen revealed Langhans giant cells and granulomas. Finally, a diagnosis of miliary tuberculosis was established because cultures of the sputum and gastric fluid were positive for Mycobacterium tuberculosis. Several weeks after a standard anti-tuberculosis regimen with 4 drugs was initiated, her clinical condition and radiological findings ameliorated. Since the initial manifestations of tuberculosis tend to be more severe during treatment of rheumatoid arthritis with tumor necrosis factor-alpha inhibitors such as infliximab due to immune suppression, we should pay closer attention to the possibility of tuberculosis infection in these patients.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Issue number3
Publication statusPublished - 03-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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