Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems

Takashi Nakano, Catherine Chin, David Mo Aung Myint, Eng Wui Tan, Peter John Hale, M. Bala Murali Krishna, John N.J. Reynolds, Jeff Wickens, Keshav M. Dani

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Existing nanoscale chemical delivery systems target diseased cells over long, sustained periods of time, typically through one-time, destructive triggering. Future directions lie in the development of fast and robust techniques capable of reproducing the pulsatile chemical activity of living organisms, thereby allowing us to mimic biofunctionality. Here, we demonstrate that by applying programmed femtosecond laser pulses to robust, nanoscale liposome structures containing dopamine, we achieve sub-second, controlled release of dopamine - a key neurotransmitter of the central nervous system - thereby replicating its release profile in the brain. The fast delivery system provides a powerful new interface with neural circuits, and to the larger range of biological functions that operate on this short timescale.

Original languageEnglish
Article number5398
JournalScientific reports
Publication statusPublished - 23-06-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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