MiR-145 promoted anoikis resistance in tumor endothelial cells

Kyoko Hida; Taisuke Kawamoto; Nako Maishi; Masahiro Morimoto; Kosuke Akiyama; Noritaka Ohga; Masanobu Shindoh; Nobuo Shinohara; Yasuhiro Hida

doi:10.1093/jb/mvx033

MiR-145 promoted anoikis resistance in tumor endothelial cells

Kyoko Hida, Taisuke Kawamoto, Nako Maishi, Masahiro Morimoto, Kosuke Akiyama, Noritaka Ohga, Masanobu Shindoh, Nobuo Shinohara, Yasuhiro Hida

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Journal of Biochemistry
Volume	162
Issue number	2
DOIs	https://doi.org/10.1093/jb/mvx033
Publication status	Published - 01-08-2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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title = "MiR-145 promoted anoikis resistance in tumor endothelial cells",

abstract = "Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.",

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doi = "10.1093/jb/mvx033",

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T1 - MiR-145 promoted anoikis resistance in tumor endothelial cells

AU - Hida, Kyoko

AU - Kawamoto, Taisuke

AU - Maishi, Nako

AU - Morimoto, Masahiro

AU - Akiyama, Kosuke

AU - Ohga, Noritaka

AU - Shindoh, Masanobu

AU - Shinohara, Nobuo

AU - Hida, Yasuhiro

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.

AB - Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.

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MiR-145 promoted anoikis resistance in tumor endothelial cells

Abstract

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