Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders

M. Yoshii, Y. Nakamoto, S. Watabe, G. Mugishima, H. Habu, T. Shiotani, Toshitaka Nabeshima

Research output: Contribution to journalArticle

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Abstract

Ro 5-4864, a specific agonist of the peripheral-type benzodiazepine receptor (PBR), elicited convulsions 2.6 times more potently in EL mice (an animal model of epilepsy) than in DDY mice (control animal). A binding assay revealed a 50% higher density of [3H]Ro 5-4864 binding sites in the mitochondrial fraction (i.e., mitochondrial benzodiazepine receptors; MBR) of the brain tissues in EL mice as compared with DDY mice. On an elevated plus- maze, EL mice showed fear responses similar to those increased in DDY mice after PBR stimulation, suggesting a hyperfunction of MBR underlying the abnormal behaviors of EL mice. In fluorometric studies using NG108-15 cells, Ro 5-4864 depolarized mitochondrial membranes and, possibly as a consequence of this, raised intracellular Ca2+. Finally, we propose that MBR could be a major target of therapy for various neurological disorders, so drugs such as 'mitochondrial membrane stabilizers' should be developed.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalJapanese Journal of Psychopharmacology
Volume18
Issue number2
Publication statusPublished - 08-07-1998
Externally publishedYes

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GABA-A Receptors
Mitochondrial Membranes
Nervous System Diseases
Fear
Epilepsy
Seizures
Animal Models
Binding Sites
Brain
Pharmaceutical Preparations
4'-chlorodiazepam

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoshii, M., Nakamoto, Y., Watabe, S., Mugishima, G., Habu, H., Shiotani, T., & Nabeshima, T. (1998). Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders. Japanese Journal of Psychopharmacology, 18(2), 49-54.
Yoshii, M. ; Nakamoto, Y. ; Watabe, S. ; Mugishima, G. ; Habu, H. ; Shiotani, T. ; Nabeshima, Toshitaka. / Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders. In: Japanese Journal of Psychopharmacology. 1998 ; Vol. 18, No. 2. pp. 49-54.
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Yoshii, M, Nakamoto, Y, Watabe, S, Mugishima, G, Habu, H, Shiotani, T & Nabeshima, T 1998, 'Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders', Japanese Journal of Psychopharmacology, vol. 18, no. 2, pp. 49-54.

Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders. / Yoshii, M.; Nakamoto, Y.; Watabe, S.; Mugishima, G.; Habu, H.; Shiotani, T.; Nabeshima, Toshitaka.

In: Japanese Journal of Psychopharmacology, Vol. 18, No. 2, 08.07.1998, p. 49-54.

Research output: Contribution to journalArticle

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Yoshii M, Nakamoto Y, Watabe S, Mugishima G, Habu H, Shiotani T et al. Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders. Japanese Journal of Psychopharmacology. 1998 Jul 8;18(2):49-54.