Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders

M. Yoshii, Y. Nakamoto, S. Watabe, G. Mugishima, H. Habu, T. Shiotani, T. Nabeshima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ro 5-4864, a specific agonist of the peripheral-type benzodiazepine receptor (PBR), elicited convulsions 2.6 times more potently in EL mice (an animal model of epilepsy) than in DDY mice (control animal). A binding assay revealed a 50% higher density of [3H]Ro 5-4864 binding sites in the mitochondrial fraction (i.e., mitochondrial benzodiazepine receptors; MBR) of the brain tissues in EL mice as compared with DDY mice. On an elevated plus- maze, EL mice showed fear responses similar to those increased in DDY mice after PBR stimulation, suggesting a hyperfunction of MBR underlying the abnormal behaviors of EL mice. In fluorometric studies using NG108-15 cells, Ro 5-4864 depolarized mitochondrial membranes and, possibly as a consequence of this, raised intracellular Ca2+. Finally, we propose that MBR could be a major target of therapy for various neurological disorders, so drugs such as 'mitochondrial membrane stabilizers' should be developed.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalJapanese Journal of Psychopharmacology
Volume18
Issue number2
Publication statusPublished - 08-07-1998
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoshii, M., Nakamoto, Y., Watabe, S., Mugishima, G., Habu, H., Shiotani, T., & Nabeshima, T. (1998). Mitochondrial benzodiazepine receptors (MBR) in association with neurolgoical disorders. Japanese Journal of Psychopharmacology, 18(2), 49-54.