MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

Toshitaka Nabeshima, Shigeru Yoshida, Hironobu Morinaka, Tsutomu Kameyama, Andrew Thurkauf, Kenner C. Rice, Arthur E. Jacobson, James A. Monn, Arthur K. Cho

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalNeuroscience Letters
Volume108
Issue number3
DOIs
Publication statusPublished - 22-01-1990
Externally publishedYes

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Dizocilpine Maleate
Amnesia
Carbon Monoxide
Phencyclidine
Neuroprotective Agents
Ischemia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nabeshima, T., Yoshida, S., Morinaka, H., Kameyama, T., Thurkauf, A., Rice, K. C., ... Cho, A. K. (1990). MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO. Neuroscience Letters, 108(3), 321-327. https://doi.org/10.1016/0304-3940(90)90661-R
Nabeshima, Toshitaka ; Yoshida, Shigeru ; Morinaka, Hironobu ; Kameyama, Tsutomu ; Thurkauf, Andrew ; Rice, Kenner C. ; Jacobson, Arthur E. ; Monn, James A. ; Cho, Arthur K. / MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO. In: Neuroscience Letters. 1990 ; Vol. 108, No. 3. pp. 321-327.
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Nabeshima, T, Yoshida, S, Morinaka, H, Kameyama, T, Thurkauf, A, Rice, KC, Jacobson, AE, Monn, JA & Cho, AK 1990, 'MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO', Neuroscience Letters, vol. 108, no. 3, pp. 321-327. https://doi.org/10.1016/0304-3940(90)90661-R

MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO. / Nabeshima, Toshitaka; Yoshida, Shigeru; Morinaka, Hironobu; Kameyama, Tsutomu; Thurkauf, Andrew; Rice, Kenner C.; Jacobson, Arthur E.; Monn, James A.; Cho, Arthur K.

In: Neuroscience Letters, Vol. 108, No. 3, 22.01.1990, p. 321-327.

Research output: Contribution to journalArticle

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T1 - MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO

AU - Nabeshima, Toshitaka

AU - Yoshida, Shigeru

AU - Morinaka, Hironobu

AU - Kameyama, Tsutomu

AU - Thurkauf, Andrew

AU - Rice, Kenner C.

AU - Jacobson, Arthur E.

AU - Monn, James A.

AU - Cho, Arthur K.

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AB - The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.

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