TY - JOUR
T1 - MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO
AU - Nabeshima, Toshitaka
AU - Yoshida, Shigeru
AU - Morinaka, Hironobu
AU - Kameyama, Tsutomu
AU - Thurkauf, Andrew
AU - Rice, Kenner C.
AU - Jacobson, Arthur E.
AU - Monn, James A.
AU - Cho, Arthur K.
PY - 1990/1/22
Y1 - 1990/1/22
N2 - The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.
AB - The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model.
UR - https://www.scopus.com/pages/publications/0025105163
UR - https://www.scopus.com/pages/publications/0025105163#tab=citedBy
U2 - 10.1016/0304-3940(90)90661-R
DO - 10.1016/0304-3940(90)90661-R
M3 - Article
C2 - 2154727
AN - SCOPUS:0025105163
SN - 0304-3940
VL - 108
SP - 321
EP - 327
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -