TY - JOUR
T1 - MK-801 increases endogenous acetylcholine release in the rat parietal cortex
T2 - a study using brain microdialysis
AU - Hasegawa, Masaya
AU - Kinoshita, Hiroshi
AU - Amano, Manabu
AU - Hasegawa, Takaaki
AU - Kameyama, Tsutomu
AU - Nabeshima, Toshitaka
PY - 1993/2/5
Y1 - 1993/2/5
N2 - Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.
AB - Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.
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U2 - 10.1016/0304-3940(93)90106-U
DO - 10.1016/0304-3940(93)90106-U
M3 - Article
C2 - 8469404
AN - SCOPUS:0027198661
SN - 0304-3940
VL - 150
SP - 53
EP - 56
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -