MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

Masaya Hasegawa, Hiroshi Kinoshita, Manabu Amano, Takaaki Hasegawa, Tsutomu Kameyama, Toshitaka Nabeshima

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Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 05-02-1993
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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