MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

Masaya Hasegawa, Hiroshi Kinoshita, Manabu Amano, Takaaki Hasegawa, Tsutomu Kameyama, Toshitaka Nabeshima

Research output: Contribution to journalArticle

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Abstract

Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalNeuroscience Letters
Volume150
Issue number1
DOIs
Publication statusPublished - 05-02-1993
Externally publishedYes

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Parietal Lobe
Dizocilpine Maleate
Microdialysis
Acetylcholine
Cholinergic Agents
Brain
Imines
Aspartic Acid

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hasegawa, Masaya ; Kinoshita, Hiroshi ; Amano, Manabu ; Hasegawa, Takaaki ; Kameyama, Tsutomu ; Nabeshima, Toshitaka. / MK-801 increases endogenous acetylcholine release in the rat parietal cortex : a study using brain microdialysis. In: Neuroscience Letters. 1993 ; Vol. 150, No. 1. pp. 53-56.
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MK-801 increases endogenous acetylcholine release in the rat parietal cortex : a study using brain microdialysis. / Hasegawa, Masaya; Kinoshita, Hiroshi; Amano, Manabu; Hasegawa, Takaaki; Kameyama, Tsutomu; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 150, No. 1, 05.02.1993, p. 53-56.

Research output: Contribution to journalArticle

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