MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

Masaya Hasegawa; Hiroshi Kinoshita; Manabu Amano; Takaaki Hasegawa; Tsutomu Kameyama; Toshitaka Nabeshima

doi:10.1016/0304-3940(93)90106-U

MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

Masaya Hasegawa
, Hiroshi Kinoshita
, Manabu Amano
, Takaaki Hasegawa
, Tsutomu Kameyama
, Toshitaka Nabeshima

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10^-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Neuroscience Letters
Volume	150
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(93)90106-U
Publication status	Published - 05-02-1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/0304-3940(93)90106-U

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title = "MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis",

abstract = "Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.",

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T2 - a study using brain microdialysis

AU - Hasegawa, Masaya

AU - Kinoshita, Hiroshi

AU - Amano, Manabu

AU - Hasegawa, Takaaki

AU - Kameyama, Tsutomu

AU - Nabeshima, Toshitaka

PY - 1993/2/5

Y1 - 1993/2/5

N2 - Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.

AB - Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10-2 M N-methyl-d-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.

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JO - Neuroscience Letters

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MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

Abstract

All Science Journal Classification (ASJC) codes

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