Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men

Sakae Miyagi, Toshinari Takamura, Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Akinori Hara, Haruki Nakamura, Keita Suzuki, Atsushi Tajima, Takayuki Kannon, Tadashi Toyama, Yasuhiro Kambayashi, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Aims/Introduction: A low insulin secretion capacity has been implicated in the high prevalence of non-obese diabetes in East Asians. As alcohol consumption alters insulin and glucose metabolism, we tested the hypothesis that alcohol consumption contributes to impaired insulin secretion and glucose intolerance in lean/normal-weight non-diabetic Japanese men. Materials and Methods: This cross-sectional study was undertaken among the residents of Shika town, Japan, between 2011 and 2017. A total of 402 non-diabetic men, including participants with normal fasting plasma glucose (FPG) and impaired FPG (FPG 5.6–6.9 mmol/L), and aged ≥40 years, were examined. FPG, the homeostasis model assessment of insulin secretion capacity (HOMA-B) and alcohol consumption were evaluated and compared between the body mass index (BMI) <25 and BMI ≥25 groups. Results: HOMA-B levels were lower in the BMI <25 group than in the BMI ≥25 group. Alcohol consumption correlated with a low HOMA-B level regardless of BMI, and, thus, the HOMA-B levels of alcohol drinkers were significantly lower in the BMI <25 group. A multivariable logistic regression analysis showed that alcohol consumption, even light-to-moderate consumption (1–25 g/day), was associated with significantly low levels of HOMA-B and impaired FPG in the BMI <25 group. Among participants with impaired FPG, a low level of HOMA-B was observed in alcohol drinkers, but not in non-drinkers. In contrast, light-to-moderate alcohol consumption was not related to HOMA-B or FPG in the BMI ≥25-group. Conclusion: Alcohol consumption, even a small amount, might contribute to reductions in HOMA-B levels and impaired FPG in lean/normal-weight Japanese men.

Original languageEnglish
Pages (from-to)869-876
Number of pages8
JournalJournal of Diabetes Investigation
Issue number5
Publication statusPublished - 05-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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