Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism

Rieko Okada, Koji Suzuki, Kazuko Nishio, Yoshiko Ishida, Sayo Kawai, Yasuyuki Goto, Mariko Naito, Kenji Wakai, Yoshinori Ito, Nobuyuki Hamajima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A widely-expressed protein tyrosine phosphatase, SHP-2, regulates apoB secretion by insulin. We hypothesised that a variation in the SHP-2 gene, PTPN11, may interact with smoking to influence serum lipid concentrations. The study comprised 794 subjects (278 males and 516 females), aged 39-88 years, who attended a health examination in Hokkaido, Japan in 2003. Subjects were genotyped for a G/A PTPN11 polymorphism (rs2301756). The mean serum LDL cholesterol, HDL cholesterol and triglyceride levels, stratified by genotype, were compared between current and non- (never or ex-) smokers. Among the AA genotype carriers, LDL cholesterol levels were significantly decreased in current vs. nonsmokers [mean ± SD, 101±34 mg/dl vs. 146±40 mg/dl; b (adjusted mean difference) = -56.0; 95% CI -102.8 to -9.3; p=0.019 after adjustment for age, sex and body mass index]. In contrast, HDL cholesterol levels were increased in current vs. non-smokers (66±5 mg/dl vs. 58±12 mg/dl; b=14.9; 95% CI 3.1 to 26.8; p=0.014 after adjustment). The interaction between a current smoking habit and the AA genotype had a significant effect on LDL and HDL cholesterol (LDL-C, p=0.039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalMolecular Medicine Reports
Volume1
Issue number4
Publication statusPublished - 01-12-2008

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Polymorphism
LDL Cholesterol
HDL Cholesterol
Smoking
Cholesterol
Genotype
Non-Receptor Type 11 Protein Tyrosine Phosphatase
Apolipoproteins B
Social Adjustment
Metabolism
Tobacco Products
Triglycerides
Genes
Serum
Health
Insulin
Habits
Lipids
Japan
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

Cite this

Okada, R., Suzuki, K., Nishio, K., Ishida, Y., Kawai, S., Goto, Y., ... Hamajima, N. (2008). Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism. Molecular Medicine Reports, 1(4), 595-598.
Okada, Rieko ; Suzuki, Koji ; Nishio, Kazuko ; Ishida, Yoshiko ; Kawai, Sayo ; Goto, Yasuyuki ; Naito, Mariko ; Wakai, Kenji ; Ito, Yoshinori ; Hamajima, Nobuyuki. / Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism. In: Molecular Medicine Reports. 2008 ; Vol. 1, No. 4. pp. 595-598.
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abstract = "A widely-expressed protein tyrosine phosphatase, SHP-2, regulates apoB secretion by insulin. We hypothesised that a variation in the SHP-2 gene, PTPN11, may interact with smoking to influence serum lipid concentrations. The study comprised 794 subjects (278 males and 516 females), aged 39-88 years, who attended a health examination in Hokkaido, Japan in 2003. Subjects were genotyped for a G/A PTPN11 polymorphism (rs2301756). The mean serum LDL cholesterol, HDL cholesterol and triglyceride levels, stratified by genotype, were compared between current and non- (never or ex-) smokers. Among the AA genotype carriers, LDL cholesterol levels were significantly decreased in current vs. nonsmokers [mean ± SD, 101±34 mg/dl vs. 146±40 mg/dl; b (adjusted mean difference) = -56.0; 95{\%} CI -102.8 to -9.3; p=0.019 after adjustment for age, sex and body mass index]. In contrast, HDL cholesterol levels were increased in current vs. non-smokers (66±5 mg/dl vs. 58±12 mg/dl; b=14.9; 95{\%} CI 3.1 to 26.8; p=0.014 after adjustment). The interaction between a current smoking habit and the AA genotype had a significant effect on LDL and HDL cholesterol (LDL-C, p=0.039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers.",
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Okada, R, Suzuki, K, Nishio, K, Ishida, Y, Kawai, S, Goto, Y, Naito, M, Wakai, K, Ito, Y & Hamajima, N 2008, 'Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism', Molecular Medicine Reports, vol. 1, no. 4, pp. 595-598.

Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism. / Okada, Rieko; Suzuki, Koji; Nishio, Kazuko; Ishida, Yoshiko; Kawai, Sayo; Goto, Yasuyuki; Naito, Mariko; Wakai, Kenji; Ito, Yoshinori; Hamajima, Nobuyuki.

In: Molecular Medicine Reports, Vol. 1, No. 4, 01.12.2008, p. 595-598.

Research output: Contribution to journalArticle

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T1 - Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism

AU - Okada, Rieko

AU - Suzuki, Koji

AU - Nishio, Kazuko

AU - Ishida, Yoshiko

AU - Kawai, Sayo

AU - Goto, Yasuyuki

AU - Naito, Mariko

AU - Wakai, Kenji

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

PY - 2008/12/1

Y1 - 2008/12/1

N2 - A widely-expressed protein tyrosine phosphatase, SHP-2, regulates apoB secretion by insulin. We hypothesised that a variation in the SHP-2 gene, PTPN11, may interact with smoking to influence serum lipid concentrations. The study comprised 794 subjects (278 males and 516 females), aged 39-88 years, who attended a health examination in Hokkaido, Japan in 2003. Subjects were genotyped for a G/A PTPN11 polymorphism (rs2301756). The mean serum LDL cholesterol, HDL cholesterol and triglyceride levels, stratified by genotype, were compared between current and non- (never or ex-) smokers. Among the AA genotype carriers, LDL cholesterol levels were significantly decreased in current vs. nonsmokers [mean ± SD, 101±34 mg/dl vs. 146±40 mg/dl; b (adjusted mean difference) = -56.0; 95% CI -102.8 to -9.3; p=0.019 after adjustment for age, sex and body mass index]. In contrast, HDL cholesterol levels were increased in current vs. non-smokers (66±5 mg/dl vs. 58±12 mg/dl; b=14.9; 95% CI 3.1 to 26.8; p=0.014 after adjustment). The interaction between a current smoking habit and the AA genotype had a significant effect on LDL and HDL cholesterol (LDL-C, p=0.039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers.

AB - A widely-expressed protein tyrosine phosphatase, SHP-2, regulates apoB secretion by insulin. We hypothesised that a variation in the SHP-2 gene, PTPN11, may interact with smoking to influence serum lipid concentrations. The study comprised 794 subjects (278 males and 516 females), aged 39-88 years, who attended a health examination in Hokkaido, Japan in 2003. Subjects were genotyped for a G/A PTPN11 polymorphism (rs2301756). The mean serum LDL cholesterol, HDL cholesterol and triglyceride levels, stratified by genotype, were compared between current and non- (never or ex-) smokers. Among the AA genotype carriers, LDL cholesterol levels were significantly decreased in current vs. nonsmokers [mean ± SD, 101±34 mg/dl vs. 146±40 mg/dl; b (adjusted mean difference) = -56.0; 95% CI -102.8 to -9.3; p=0.019 after adjustment for age, sex and body mass index]. In contrast, HDL cholesterol levels were increased in current vs. non-smokers (66±5 mg/dl vs. 58±12 mg/dl; b=14.9; 95% CI 3.1 to 26.8; p=0.014 after adjustment). The interaction between a current smoking habit and the AA genotype had a significant effect on LDL and HDL cholesterol (LDL-C, p=0.039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers.

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