Modified neutrophil-platelet score as a promising marker for stratified surgical and oncological outcomes of patients with gastric cancer

Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Yusuke Omura, Kurando Kusunoki, Chengzeng Yin, Shozo Ide, Takahito Kitajima, Yuki Koike, Hiroyuki Fujikawa, Hiromi Yasuda, Yoshiki Okita, Junichiro Hiro, Shigeyuki Yoshiyama, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: Gastric cancer (GC) is a common malignancy, especially in East Asian countries. There is emerging evidence that circulating neutrophil and platelet levels correlate with cancer progression. We evaluated the short- and long-term outcomes of GC patients systemically, to compare the original neutrophil–platelet score (NPS) and our modified NPS (mNPS). Methods: We analyzed the original pre-operative NPS and the mNPS of 621 GC patients. Results: Racial differences between the United Kingdom and East Asian countries accounted for compelling deviation in classification using the original NPS, which could not reliably stratify the prognoses of Japanese GC patients. We developed the mNPS using appropriate cutoff levels for pre-operative neutrophils and platelets, and demonstrated that the pre-operative mNPS was significantly correlated with all of the well-established clinicopathological factors for disease development, including advanced T stage, venous and lymphatic vessel invasion, lymph node/peritoneal /distant metastasis, and tumor-node-metastasis stage. The pre-operative mNPS could stratify prognostication for both overall survival (OS) and disease-free survival (DFS): a high pre-operative mNPS was an independent prognostic factor for the OS and DFS of GC patients and also an independent predictor of post-operative surgical site infection after gastrectomy. Conclusion: Calculating the mNPS could help clinicians to stratify the surgical and oncological risks of patients with GC.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalSurgery Today
Volume50
Issue number3
DOIs
Publication statusPublished - 01-03-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

Fingerprint

Dive into the research topics of 'Modified neutrophil-platelet score as a promising marker for stratified surgical and oncological outcomes of patients with gastric cancer'. Together they form a unique fingerprint.

Cite this