Abstract
We investigated the effects of the farnesyl transferase inhibitor (FTI) manumycin and the MEK inhibitor PD98059 on growth of human pancreatic cancer, with mutant (SUIT2) or wild-type (BxPC-3) K-ras, xenografted into nude mice. Tumor growth was not reduced by either of the agents at a dose of 3 mg/kg without irradiation. Growth of SUIT2 irradiated at 15 Gy or 30 Gy was reduced by manumycin and PD98059: at 15 Gy, tumor volume doubling time (TVDT) increased from 18.6±3.8 to 36.3±14.2 days with PD98059 (p<0.05); at 30 Gy, TVDT increased from 32.8±6.8 to 70.5±10.5 days and 70.7±1.5 days, respectively. Manumycin tended to reduce growth of BxPC-3, but the difference in TVDT was not statistically significant. PD98059 significantly increased the TVDT of BxPC-3 at 30 Gy from 34.4±18 to 62.6±9.8 at 30 Gy. The present results suggest that Ras signaling pathways are potential targets for manipulation of radiosensitivity, and that induction of an alternative pathway may enhance radiosensitivity of pancreatic cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1525-1528 |
| Number of pages | 4 |
| Journal | Oncology reports |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 09-2003 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
