Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations

Y. H. Zhang, T. Yoshida, K. Isobe, S. M.J. Rahman, F. Nagase, L. Ding, I. Nakashima

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Glycyrrhizin (GL), a saponin fraction of licorice with defined chemical structure, was shown to display a definite action in vitro augmenting the cell-surface expression of H-2 class I antigens as well as class I gene transcription on various tumour cell lines. The magnitude of augmentation was varied among eight different cell lines tested, but reached more than three times. It was also found that GL enhanced the expression of H-2D(d) antigens in some normal cell populations in vivo. The augmentation of H-2 class I antigens on tumour cell lines in vitro was probably not mediated by the interferon, which might have been produced by the cultured cells. These findings may suggest a new immunopharmacological action of GL.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalImmunology
Volume70
Issue number3
Publication statusPublished - 01-01-1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations'. Together they form a unique fingerprint.

  • Cite this

    Zhang, Y. H., Yoshida, T., Isobe, K., Rahman, S. M. J., Nagase, F., Ding, L., & Nakashima, I. (1990). Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations. Immunology, 70(3), 405-410.