Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate

Tracee Scalise Panetti, Magnus K. Magnusson, Olivier Peyruchaud, Qinghong Zhang, Mary E. Cooke, Takao Sakai, Deane F. Mosher

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SPP) are lipid mediators released upon platelet activation. The concentration of LPA in serum is estimated at 1-10 μM whereas the concentration in plasma is considerably less [1]. The SPP concentration in serum is 0.5 μM, approximately two-fold higher than the plasma concentration [1]. The lipids are present during tissue injury and promote cellular processes involved in wound repair [2]. LPA and SPP have multiple effects on cells, many of which are pertinent to wound healing and require that the cells interact in some fashion with components of the extracellular matrix. This review focuses on modulation of cell adhesion, cell migration, collagen gel contraction, and fibronectin matrix assembly by LPA and SPP.

Original languageEnglish
Pages (from-to)93-106
Number of pages14
JournalProstaglandins and Other Lipid Mediators
Volume64
Issue number1-4
DOIs
Publication statusPublished - 04-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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