Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)

Kan Shimpo; Chikako Ida; Takeshi Chihara; Hidehiko Beppu; Takaaki Kaneko; Hiroshi Kuzuya

Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)

Kan Shimpo, Chikako Ida, Takeshi Chihara, Hidehiko Beppu, Takaaki Kaneko, Hiroshi Kuzuya

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the modulating effects of freeze-dried whole-leaf Aloe arborescens var. natalensis (hereinafter called ALOE) on the hepatic activities of quinine reductase (QR), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450 (CYP) 2E1-mediated p-nitrophenol (PNP) hydroxylase in rats. Male F344 rats (4 weeks old) were fed a basal diet or experimental diets containing 5%ALOE for 5 weeks. Dietary administration of ALOE significantly enhanced the activities of QR and ADH compared with controls. In contrast, the PNP hydroxylase activity was significantly reduced in rats fed the ALOE diet. On the other hand, no significant changes were observed in the ALDH activity in the ALOE-treated rats. These results indicate that ALOE may have beneficial effects on ethanol metabolism and toxicity.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	Natural Medicines
Volume	58
Issue number	1
Publication status	Published - 02-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine

Cite this

@article{6f701dbe442b4f6c9e70625ef0d863dc,

title = "Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)",

abstract = "We examined the modulating effects of freeze-dried whole-leaf Aloe arborescens var. natalensis (hereinafter called ALOE) on the hepatic activities of quinine reductase (QR), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450 (CYP) 2E1-mediated p-nitrophenol (PNP) hydroxylase in rats. Male F344 rats (4 weeks old) were fed a basal diet or experimental diets containing 5%ALOE for 5 weeks. Dietary administration of ALOE significantly enhanced the activities of QR and ADH compared with controls. In contrast, the PNP hydroxylase activity was significantly reduced in rats fed the ALOE diet. On the other hand, no significant changes were observed in the ALDH activity in the ALOE-treated rats. These results indicate that ALOE may have beneficial effects on ethanol metabolism and toxicity.",

author = "Kan Shimpo and Chikako Ida and Takeshi Chihara and Hidehiko Beppu and Takaaki Kaneko and Hiroshi Kuzuya",

year = "2004",

month = feb,

language = "English",

volume = "58",

pages = "27--30",

journal = "Natural Medicines",

issn = "1340-3443",

publisher = "Springer Japan",

number = "1",

}

TY - JOUR

T1 - Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)

AU - Shimpo, Kan

AU - Ida, Chikako

AU - Chihara, Takeshi

AU - Beppu, Hidehiko

AU - Kaneko, Takaaki

AU - Kuzuya, Hiroshi

PY - 2004/2

Y1 - 2004/2

N2 - We examined the modulating effects of freeze-dried whole-leaf Aloe arborescens var. natalensis (hereinafter called ALOE) on the hepatic activities of quinine reductase (QR), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450 (CYP) 2E1-mediated p-nitrophenol (PNP) hydroxylase in rats. Male F344 rats (4 weeks old) were fed a basal diet or experimental diets containing 5%ALOE for 5 weeks. Dietary administration of ALOE significantly enhanced the activities of QR and ADH compared with controls. In contrast, the PNP hydroxylase activity was significantly reduced in rats fed the ALOE diet. On the other hand, no significant changes were observed in the ALDH activity in the ALOE-treated rats. These results indicate that ALOE may have beneficial effects on ethanol metabolism and toxicity.

AB - We examined the modulating effects of freeze-dried whole-leaf Aloe arborescens var. natalensis (hereinafter called ALOE) on the hepatic activities of quinine reductase (QR), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450 (CYP) 2E1-mediated p-nitrophenol (PNP) hydroxylase in rats. Male F344 rats (4 weeks old) were fed a basal diet or experimental diets containing 5%ALOE for 5 weeks. Dietary administration of ALOE significantly enhanced the activities of QR and ADH compared with controls. In contrast, the PNP hydroxylase activity was significantly reduced in rats fed the ALOE diet. On the other hand, no significant changes were observed in the ALDH activity in the ALOE-treated rats. These results indicate that ALOE may have beneficial effects on ethanol metabolism and toxicity.

UR - http://www.scopus.com/inward/record.url?scp=1642544737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642544737&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:1642544737

SN - 1340-3443

VL - 58

SP - 27

EP - 30

JO - Natural Medicines

JF - Natural Medicines

IS - 1

ER -

Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this