TY - JOUR
T1 - Molecular analysis of the h-warts/LATS1 gene in human breast cancer.
AU - Morinaga, N.
AU - Shitara, Y.
AU - Yanagita, Y.
AU - Koida, T.
AU - Kimura, M.
AU - Asao, T.
AU - Kimijima, I.
AU - Takenoshita, S.
AU - Hirota, T.
AU - Saya, H.
AU - Kuwano, H.
PY - 2000/12
Y1 - 2000/12
N2 - Loss of heterozygosity (LOH) on chromosome 6q is often observed in breast cancer, suggesting the existence of a putative tumor suppressor. Recently, a human homolog of the Drosophila warts tumor suppressor gene, h-warts/LATS1, was identified and mapped at chromosome 6q24-25.1. Mutation analysis of the h-warts/LATS1 was performed using 25 breast cancer tissues by RT-PCR SSCP analysis. Although LOH of the h-warts/LATS1 was found in one patient, no mutations were found. Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer.
AB - Loss of heterozygosity (LOH) on chromosome 6q is often observed in breast cancer, suggesting the existence of a putative tumor suppressor. Recently, a human homolog of the Drosophila warts tumor suppressor gene, h-warts/LATS1, was identified and mapped at chromosome 6q24-25.1. Mutation analysis of the h-warts/LATS1 was performed using 25 breast cancer tissues by RT-PCR SSCP analysis. Although LOH of the h-warts/LATS1 was found in one patient, no mutations were found. Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer.
UR - http://www.scopus.com/inward/record.url?scp=0034546548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034546548&partnerID=8YFLogxK
U2 - 10.3892/ijo.17.6.1125
DO - 10.3892/ijo.17.6.1125
M3 - Article
C2 - 11078797
AN - SCOPUS:0034546548
SN - 1019-6439
VL - 17
SP - 1125
EP - 1129
JO - International journal of oncology
JF - International journal of oncology
IS - 6
ER -