Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

Akifumi Endo; Ken Watanabe; Tamae Ohye; Kyoko Suzuki; Tomoyo Matsubara; Norio Shimizu; Hiroki Kurahashi; Tetsushi Yoshikawa; Harutaka Katano; Naoki Inoue; Kohsuke Imai; Masatoshi Takagi; Tomohiro Morio; Shuki Mizutani

doi:10.1093/cid/ciu323

Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

Akifumi Endo, Ken Watanabe, Tamae Ohye, Kyoko Suzuki, Tomoyo Matsubara, Norio Shimizu, Hiroki Kurahashi, Tetsushi Yoshikawa, Harutaka Katano, Naoki Inoue, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Shuki Mizutani

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

Original language	English
Pages (from-to)	545-548
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	59
Issue number	4
DOIs	https://doi.org/10.1093/cid/ciu323
Publication status	Published - 15-08-2014

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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Endo, A., Watanabe, K., Ohye, T., Suzuki, K., Matsubara, T., Shimizu, N., Kurahashi, H., Yoshikawa, T., Katano, H., Inoue, N., Imai, K., Takagi, M., Morio, T., & Mizutani, S. (2014). Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. Clinical Infectious Diseases, 59(4), 545-548. https://doi.org/10.1093/cid/ciu323

Endo, Akifumi ; Watanabe, Ken ; Ohye, Tamae ; Suzuki, Kyoko ; Matsubara, Tomoyo ; Shimizu, Norio ; Kurahashi, Hiroki ; Yoshikawa, Tetsushi ; Katano, Harutaka ; Inoue, Naoki ; Imai, Kohsuke ; Takagi, Masatoshi ; Morio, Tomohiro ; Mizutani, Shuki. / Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. In: Clinical Infectious Diseases. 2014 ; Vol. 59, No. 4. pp. 545-548.

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title = "Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency",

abstract = "It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.",

author = "Akifumi Endo and Ken Watanabe and Tamae Ohye and Kyoko Suzuki and Tomoyo Matsubara and Norio Shimizu and Hiroki Kurahashi and Tetsushi Yoshikawa and Harutaka Katano and Naoki Inoue and Kohsuke Imai and Masatoshi Takagi and Tomohiro Morio and Shuki Mizutani",

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Endo, A, Watanabe, K, Ohye, T, Suzuki, K, Matsubara, T, Shimizu, N, Kurahashi, H , Yoshikawa, T, Katano, H, Inoue, N, Imai, K, Takagi, M, Morio, T & Mizutani, S 2014, 'Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency', Clinical Infectious Diseases, vol. 59, no. 4, pp. 545-548. https://doi.org/10.1093/cid/ciu323

Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. / Endo, Akifumi; Watanabe, Ken; Ohye, Tamae; Suzuki, Kyoko; Matsubara, Tomoyo; Shimizu, Norio; Kurahashi, Hiroki ; Yoshikawa, Tetsushi; Katano, Harutaka; Inoue, Naoki; Imai, Kohsuke; Takagi, Masatoshi; Morio, Tomohiro; Mizutani, Shuki.

In: Clinical Infectious Diseases, Vol. 59, No. 4, 15.08.2014, p. 545-548.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

AU - Endo, Akifumi

AU - Watanabe, Ken

AU - Ohye, Tamae

AU - Suzuki, Kyoko

AU - Matsubara, Tomoyo

AU - Shimizu, Norio

AU - Kurahashi, Hiroki

AU - Yoshikawa, Tetsushi

AU - Katano, Harutaka

AU - Inoue, Naoki

AU - Imai, Kohsuke

AU - Takagi, Masatoshi

AU - Morio, Tomohiro

AU - Mizutani, Shuki

PY - 2014/8/15

Y1 - 2014/8/15

N2 - It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

AB - It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

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SN - 1058-4838

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ER -

Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

Abstract

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