Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

Akifumi Endo; Ken Watanabe; Tamae Ohye; Kyoko Suzuki; Tomoyo Matsubara; Norio Shimizu; Hiroki Kurahashi; Tetsushi Yoshikawa; Harutaka Katano; Naoki Inoue; Kohsuke Imai; Masatoshi Takagi; Tomohiro Morio; Shuki Mizutani

doi:10.1093/cid/ciu323

Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

Akifumi Endo
, Ken Watanabe
, Tamae Ohye
, Kyoko Suzuki
, Tomoyo Matsubara
, Norio Shimizu
, Hiroki Kurahashi
, Tetsushi Yoshikawa
, Harutaka Katano
, Naoki Inoue
, Kohsuke Imai
, Masatoshi Takagi
, Tomohiro Morio
, Shuki Mizutani

Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)

Abstract

It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

Original language	English
Pages (from-to)	545-548
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	59
Issue number	4
DOIs	https://doi.org/10.1093/cid/ciu323
Publication status	Published - 15-08-2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciu323

Cite this

Endo, A., Watanabe, K., Ohye, T., Suzuki, K., Matsubara, T., Shimizu, N., Kurahashi, H., Yoshikawa, T., Katano, H., Inoue, N., Imai, K., Takagi, M., Morio, T., & Mizutani, S. (2014). Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. Clinical Infectious Diseases, 59(4), 545-548. https://doi.org/10.1093/cid/ciu323

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title = "Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency",

abstract = "It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.",

keywords = "CiHHV-6, HHV-6, Hemophagocytic Syndrome, Thrombotic microangiopathy, X-SCID",

author = "Akifumi Endo and Ken Watanabe and Tamae Ohye and Kyoko Suzuki and Tomoyo Matsubara and Norio Shimizu and Hiroki Kurahashi and Tetsushi Yoshikawa and Harutaka Katano and Naoki Inoue and Kohsuke Imai and Masatoshi Takagi and Tomohiro Morio and Shuki Mizutani",

year = "2014",

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doi = "10.1093/cid/ciu323",

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Endo, A, Watanabe, K, Ohye, T, Suzuki, K, Matsubara, T, Shimizu, N, Kurahashi, H , Yoshikawa, T, Katano, H, Inoue, N, Imai, K, Takagi, M, Morio, T & Mizutani, S 2014, 'Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency', Clinical Infectious Diseases, vol. 59, no. 4, pp. 545-548. https://doi.org/10.1093/cid/ciu323

TY - JOUR

T1 - Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

AU - Endo, Akifumi

AU - Watanabe, Ken

AU - Ohye, Tamae

AU - Suzuki, Kyoko

AU - Matsubara, Tomoyo

AU - Shimizu, Norio

AU - Kurahashi, Hiroki

AU - Yoshikawa, Tetsushi

AU - Katano, Harutaka

AU - Inoue, Naoki

AU - Imai, Kohsuke

AU - Takagi, Masatoshi

AU - Morio, Tomohiro

AU - Mizutani, Shuki

PY - 2014/8/15

Y1 - 2014/8/15

N2 - It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

AB - It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

KW - CiHHV-6

KW - HHV-6

KW - Hemophagocytic Syndrome

KW - Thrombotic microangiopathy

KW - X-SCID

UR - https://www.scopus.com/pages/publications/84905043671

UR - https://www.scopus.com/pages/publications/84905043671#tab=citedBy

U2 - 10.1093/cid/ciu323

DO - 10.1093/cid/ciu323

M3 - Article

C2 - 24803376

AN - SCOPUS:84905043671

SN - 1058-4838

VL - 59

SP - 545

EP - 548

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 4

ER -

Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency

Abstract

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