TY - JOUR
T1 - Molecular Biological Analysis of Metallo-β-lactamase-producing Acinetobacter baumannii Isolated from 4 Children in the NICU and Environmental Investigation
AU - Yokozawa, Takayuki
AU - Houchigai, Taisuke
AU - Dobashi, Naoko
AU - Ichinose, Naoki
AU - Oda, Toshimi
AU - Kobayashi, Takashi
AU - Aoki, Shigeyuki
AU - Matsui, Mari
AU - Arakawa, Yoshichika
PY - 2012
Y1 - 2012
N2 - Acinetobacter spp. Is one of the major bacteria strains causing ventilator-associated nosocomial infection. Emergence of antimicrobial resistant Acinetobacter strain has occurred, and patients undergoing chemotherapy or immature infant may suffer significant impacts from A. baumannii. A. Baumannii which produces metallo-β-lactamase (MBL-producing A. Baumannii) were detected from 4 infants in our NICU. We suspected nosocomial infections based on pulsed-field gel electrophoresis (PFGE), but no MBL-producing A. Baumannii were detected by three NICU environmental investigations conducted by the ICT. However, MBL-producing A. Baumannii was isolated in the ventilator circuit and environment around the water supply system in the NICU. On the other hand, examination of a tracheal tube, obtained from a patient with MBL-producing A. Baumannii isolated from the endotracheal aspirates, detected only non-MBL-producing A. Baumannii, suggesting that two PFGE strains originated from the same homologies. If nosocomial-infection due to antimicrobial-resistant microbes is suspected, the presence of different susceptible strains of bacteria should be considered.
AB - Acinetobacter spp. Is one of the major bacteria strains causing ventilator-associated nosocomial infection. Emergence of antimicrobial resistant Acinetobacter strain has occurred, and patients undergoing chemotherapy or immature infant may suffer significant impacts from A. baumannii. A. Baumannii which produces metallo-β-lactamase (MBL-producing A. Baumannii) were detected from 4 infants in our NICU. We suspected nosocomial infections based on pulsed-field gel electrophoresis (PFGE), but no MBL-producing A. Baumannii were detected by three NICU environmental investigations conducted by the ICT. However, MBL-producing A. Baumannii was isolated in the ventilator circuit and environment around the water supply system in the NICU. On the other hand, examination of a tracheal tube, obtained from a patient with MBL-producing A. Baumannii isolated from the endotracheal aspirates, detected only non-MBL-producing A. Baumannii, suggesting that two PFGE strains originated from the same homologies. If nosocomial-infection due to antimicrobial-resistant microbes is suspected, the presence of different susceptible strains of bacteria should be considered.
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U2 - 10.4058/jsei.27.38
DO - 10.4058/jsei.27.38
M3 - Article
AN - SCOPUS:85006642662
SN - 1882-532X
VL - 27
SP - 38
EP - 43
JO - Japanese Journal of Environmental Infections
JF - Japanese Journal of Environmental Infections
IS - 1
ER -