Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid, Clement K.M. Tsui, Yohei Doi, Anand Deshmukh, Christi L. McElheny, William C. Bachman, Erin L. Fowler, Ahmed Albishawi, Kamran Mushtaq, Emad B. Ibrahim, Sanjay H. Doiphode, Manal M. Hamed, Muna A. Almaslmani, Abdullatif Alkhal, Adeel A. Butt, Ali S. Omrani

Research output: Contribution to journalArticlepeer-review

Abstract

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

Original languageEnglish
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
DOIs
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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