Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid; Clement K.M. Tsui; Yohei Doi; Anand Deshmukh; Christi L. McElheny; William C. Bachman; Erin L. Fowler; Ahmed Albishawi; Kamran Mushtaq; Emad B. Ibrahim; Sanjay H. Doiphode; Manal M. Hamed; Muna A. Almaslmani; Abdullatif Alkhal; Adeel A. Butt; Ali S. Omrani

doi:10.1007/s10096-021-04185-7

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid, Clement K.M. Tsui, Yohei Doi, Anand Deshmukh, Christi L. McElheny, William C. Bachman, Erin L. Fowler, Ahmed Albishawi, Kamran Mushtaq, Emad B. Ibrahim, Sanjay H. Doiphode, Manal M. Hamed, Muna A. Almaslmani, Abdullatif Alkhal, Adeel A. Butt, Ali S. Omrani

Microbiology

Research output: Contribution to journal › Article › peer-review

Abstract

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla_NDM-1 (45; 30.2%) and bla_OXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

Original language	English
Journal	European Journal of Clinical Microbiology and Infectious Diseases
DOIs	https://doi.org/10.1007/s10096-021-04185-7
Publication status	Accepted/In press - 2021

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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Abid, F. B., Tsui, C. K. M., Doi, Y., Deshmukh, A., McElheny, C. L., Bachman, W. C., Fowler, E. L., Albishawi, A., Mushtaq, K., Ibrahim, E. B., Doiphode, S. H., Hamed, M. M., Almaslmani, M. A., Alkhal, A., Butt, A. A., & Omrani, A. S. (Accepted/In press). Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar. European Journal of Clinical Microbiology and Infectious Diseases. https://doi.org/10.1007/s10096-021-04185-7

Abid, Fatma Ben ; Tsui, Clement K.M. ; Doi, Yohei ; Deshmukh, Anand ; McElheny, Christi L. ; Bachman, William C. ; Fowler, Erin L. ; Albishawi, Ahmed ; Mushtaq, Kamran ; Ibrahim, Emad B. ; Doiphode, Sanjay H. ; Hamed, Manal M. ; Almaslmani, Muna A. ; Alkhal, Abdullatif ; Butt, Adeel A. ; Omrani, Ali S. / Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar. In: European Journal of Clinical Microbiology and Infectious Diseases. 2021.

@article{3cc206a70805463ba7f49ca2676d6836,

title = "Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar",

abstract = "One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).",

author = "Abid, {Fatma Ben} and Tsui, {Clement K.M.} and Yohei Doi and Anand Deshmukh and McElheny, {Christi L.} and Bachman, {William C.} and Fowler, {Erin L.} and Ahmed Albishawi and Kamran Mushtaq and Ibrahim, {Emad B.} and Doiphode, {Sanjay H.} and Hamed, {Manal M.} and Almaslmani, {Muna A.} and Abdullatif Alkhal and Butt, {Adeel A.} and Omrani, {Ali S.}",

note = "Funding Information: Open access funding provided by the Qatar National Library. The study was funded by research grants from the Medical Research Centre at Hamad Medical Corporation, Doha (MRC-16134/16 to F.B.) and from the National Institutes of Health (R01AI104895, R21AI135522, and R21AI151362 to Y.D.). Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

doi = "10.1007/s10096-021-04185-7",

language = "English",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

issn = "0934-9723",

publisher = "Springer Verlag",

}

Abid, FB, Tsui, CKM, Doi, Y, Deshmukh, A, McElheny, CL, Bachman, WC, Fowler, EL, Albishawi, A, Mushtaq, K, Ibrahim, EB, Doiphode, SH, Hamed, MM, Almaslmani, MA, Alkhal, A, Butt, AA & Omrani, AS 2021, 'Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar', European Journal of Clinical Microbiology and Infectious Diseases. https://doi.org/10.1007/s10096-021-04185-7

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar. / Abid, Fatma Ben; Tsui, Clement K.M.; Doi, Yohei; Deshmukh, Anand; McElheny, Christi L.; Bachman, William C.; Fowler, Erin L.; Albishawi, Ahmed; Mushtaq, Kamran; Ibrahim, Emad B.; Doiphode, Sanjay H.; Hamed, Manal M.; Almaslmani, Muna A.; Alkhal, Abdullatif; Butt, Adeel A.; Omrani, Ali S.

In: European Journal of Clinical Microbiology and Infectious Diseases, 2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

AU - Abid, Fatma Ben

AU - Tsui, Clement K.M.

AU - Doi, Yohei

AU - Deshmukh, Anand

AU - McElheny, Christi L.

AU - Bachman, William C.

AU - Fowler, Erin L.

AU - Albishawi, Ahmed

AU - Mushtaq, Kamran

AU - Ibrahim, Emad B.

AU - Doiphode, Sanjay H.

AU - Hamed, Manal M.

AU - Almaslmani, Muna A.

AU - Alkhal, Abdullatif

AU - Butt, Adeel A.

AU - Omrani, Ali S.

N1 - Funding Information: Open access funding provided by the Qatar National Library. The study was funded by research grants from the Medical Research Centre at Hamad Medical Corporation, Doha (MRC-16134/16 to F.B.) and from the National Institutes of Health (R01AI104895, R21AI135522, and R21AI151362 to Y.D.). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

AB - One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

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U2 - 10.1007/s10096-021-04185-7

DO - 10.1007/s10096-021-04185-7

M3 - Article

AN - SCOPUS:85101197962

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

ER -

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

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