Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid; Clement K.M. Tsui; Yohei Doi; Anand Deshmukh; Christi L. McElheny; William C. Bachman; Erin L. Fowler; Ahmed Albishawi; Kamran Mushtaq; Emad B. Ibrahim; Sanjay H. Doiphode; Manal M. Hamed; Muna A. Almaslmani; Abdullatif Alkhal; Adeel A. Butt; Ali S. Omrani

doi:10.1007/s10096-021-04185-7

Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Fatma Ben Abid, Clement K.M. Tsui, Yohei Doi, Anand Deshmukh, Christi L. McElheny, William C. Bachman, Erin L. Fowler, Ahmed Albishawi, Kamran Mushtaq, Emad B. Ibrahim, Sanjay H. Doiphode, Manal M. Hamed, Muna A. Almaslmani, Abdullatif Alkhal, Adeel A. Butt, Ali S. Omrani

Microbiology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla_NDM-1 (45; 30.2%) and bla_OXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

Original language	English
Pages (from-to)	1779-1785
Number of pages	7
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	40
Issue number	8
DOIs	https://doi.org/10.1007/s10096-021-04185-7
Publication status	Published - 08-2021

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

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10.1007/s10096-021-04185-7

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Abid, F. B., Tsui, C. K. M., Doi, Y., Deshmukh, A., McElheny, C. L., Bachman, W. C., Fowler, E. L., Albishawi, A., Mushtaq, K., Ibrahim, E. B., Doiphode, S. H., Hamed, M. M., Almaslmani, M. A., Alkhal, A., Butt, A. A., & Omrani, A. S. (2021). Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar. European Journal of Clinical Microbiology and Infectious Diseases, 40(8), 1779-1785. https://doi.org/10.1007/s10096-021-04185-7

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abstract = "One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).",

author = "Abid, {Fatma Ben} and Tsui, {Clement K.M.} and Yohei Doi and Anand Deshmukh and McElheny, {Christi L.} and Bachman, {William C.} and Fowler, {Erin L.} and Ahmed Albishawi and Kamran Mushtaq and Ibrahim, {Emad B.} and Doiphode, {Sanjay H.} and Hamed, {Manal M.} and Almaslmani, {Muna A.} and Abdullatif Alkhal and Butt, {Adeel A.} and Omrani, {Ali S.}",

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Abid, FB, Tsui, CKM, Doi, Y, Deshmukh, A, McElheny, CL, Bachman, WC, Fowler, EL, Albishawi, A, Mushtaq, K, Ibrahim, EB, Doiphode, SH, Hamed, MM, Almaslmani, MA, Alkhal, A, Butt, AA & Omrani, AS 2021, 'Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar', European Journal of Clinical Microbiology and Infectious Diseases, vol. 40, no. 8, pp. 1779-1785. https://doi.org/10.1007/s10096-021-04185-7

TY - JOUR

T1 - Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

AU - Abid, Fatma Ben

AU - Tsui, Clement K.M.

AU - Doi, Yohei

AU - Deshmukh, Anand

AU - McElheny, Christi L.

AU - Bachman, William C.

AU - Fowler, Erin L.

AU - Albishawi, Ahmed

AU - Mushtaq, Kamran

AU - Ibrahim, Emad B.

AU - Doiphode, Sanjay H.

AU - Hamed, Manal M.

AU - Almaslmani, Muna A.

AU - Alkhal, Abdullatif

AU - Butt, Adeel A.

AU - Omrani, Ali S.

PY - 2021/8

Y1 - 2021/8

N2 - One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

AB - One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).

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Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

Abstract

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