TY - JOUR
T1 - Molecular cloning of the human Nurr1 gene
T2 - Characterization of the human gene and cDNAs
AU - Ichinose, Hiroshi
AU - Ohye, Tamae
AU - Suzuki, Takahiro
AU - Sumi-Ichinose, Chiho
AU - Nomura, Takahide
AU - Hagino, Yasumichi
AU - Nagatsu, Toshiharu
N1 - Funding Information:
This work was supported by grants-in-aid from the Ministry of Health and Welfare of Japan, the Ministry of Education, Science, Sports, and Culture of Japan, the Fujita Health University, and the Yamanouchi Foundation for Research on Metabolic Disorders.
PY - 1999/4/16
Y1 - 1999/4/16
N2 - Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing dopaminergic neurons. Recently, it was demonstrated that Nurr1 is critical for midbrain dopaminergic cell differentiation. In order to investigate a possible relation of Nurr1 with the pathogenesis of Parkinson's disease or other neuropsychiatric disorders, we have cloned and characterized the human Nurr1 gene. The gene exists as a single copy in the human genome and comprises eight exons spanning 8 kb. We determined the complete nucleotide sequence and flanking regions of the gene. Potential regulatory regions included consensus binding sites for NF-κB, CREB, and Spl. Isolation of human Nurr1 cDNAs from fetal brain suggested the presence of a new splicing variant of Nurr1 in the human brain.
AB - Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing dopaminergic neurons. Recently, it was demonstrated that Nurr1 is critical for midbrain dopaminergic cell differentiation. In order to investigate a possible relation of Nurr1 with the pathogenesis of Parkinson's disease or other neuropsychiatric disorders, we have cloned and characterized the human Nurr1 gene. The gene exists as a single copy in the human genome and comprises eight exons spanning 8 kb. We determined the complete nucleotide sequence and flanking regions of the gene. Potential regulatory regions included consensus binding sites for NF-κB, CREB, and Spl. Isolation of human Nurr1 cDNAs from fetal brain suggested the presence of a new splicing variant of Nurr1 in the human brain.
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U2 - 10.1016/S0378-1119(99)00065-7
DO - 10.1016/S0378-1119(99)00065-7
M3 - Article
C2 - 10216262
AN - SCOPUS:0033574750
SN - 0378-1119
VL - 230
SP - 233
EP - 239
JO - Gene
JF - Gene
IS - 2
ER -
