Molecular diagnosis of egg allergy

Jean Christoph Caubet, Yasuto Kondo, Atsuo Urisu, Anna Nowak-Wȩgrzyn

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)

Abstract

Purpose of review: Allergy to hen's egg is common in infancy and childhood. Oral food challenges are often required to diagnose egg allergy, because of the limitation in the diagnostic accuracy of skin test and specific IgE to egg white. New molecular diagnostic technologies have been recently introduced into allergological research. In this article, we will review the recent literature regarding the potential value of these tests for the clinical management of egg-allergic patients. Recent findings: Component-resolved diagnosis that can be combined with the microarray technology is promising as measurement of specific IgE antibodies to individual egg white components has been shown to predict different clinical patterns of egg allergy. Specific IgE to ovomucoid has been identified as a risk factor for persistent allergy and could indicate reactivity to heated egg. Ovomucoid and ovalbumin IgE and IgG4-binding epitope profiling could also help distinguish different clinical phenotypes of egg allergy. Particularly, egg-allergic patients with IgE antibodies reacting against sequential epitopes tend to have more persistent allergy. Summary: Using recombinant allergens, IgE-binding epitopes, and microarrays, molecular-based technologies show promising results. However, none of these tests is ready to be used in clinical practice and oral food challenge remains the standard for the diagnosis of egg allergy.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalCurrent opinion in allergy and clinical immunology
Volume11
Issue number3
DOIs
Publication statusPublished - 01-06-2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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