Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States

Jennifer M. Adams-Haduch, Ezenwa O. Onuoha, Tatiana Bogdanovich, Guo Bao Tian, Jonas Marschall, Carl M. Urban, Brad J. Spellberg, Diane Rhee, Diane C. Halstead, Anthony W. Pasculle, Yohei Doi

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Acinetobacter baumannii is emerging as an important nosocomial pathogen worldwide. We report molecular epidemiology of 65 carbapenem-nonsusceptible A. baumannii isolates identified from hospitals in New York, Pennsylvania, Florida, Missouri, Nevada, and California between 2008 and 2009. All isolates were subjected to pulsed-field gel electrophoresis (PFGE). Select isolates then underwent multilocus sequence typing (MLST). While the PFGE patterns tended to cluster within each hospital, sequence types (STs) belonging to the clonal complex 92 (CC92) and the pan-European clonal lineage II (EUII; worldwide clonal lineage 2) were predominant in all hospitals. Of them, ST122 and ST208 were the most common and were found in four of the six hospitals. Isolates belonging to the pan-European clonal lineages I and III were identified in one hospital each. Carbapenemase-encoding genes bla OXA-23 and/or ISAba1-bla OXA-51-like were present among the majority of isolates. These findings suggest that carbapenem-nonsusceptible A. baumannii isolates found in U.S. hospitals constitute part of the global epidemic driven by CC92, but have unique STs other than ST92, which may be spreading by means of patient transfer between health care facilities within the United States.

Original languageEnglish
Pages (from-to)3849-3854
Number of pages6
JournalJournal of clinical microbiology
Volume49
Issue number11
DOIs
Publication statusPublished - 01-11-2011

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Acinetobacter baumannii
Carbapenems
Molecular Epidemiology
Pulsed Field Gel Electrophoresis
Multilocus Sequence Typing
Patient Transfer
Health Facilities
Delivery of Health Care
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Adams-Haduch, J. M., Onuoha, E. O., Bogdanovich, T., Tian, G. B., Marschall, J., Urban, C. M., ... Doi, Y. (2011). Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States. Journal of clinical microbiology, 49(11), 3849-3854. https://doi.org/10.1128/JCM.00619-11
Adams-Haduch, Jennifer M. ; Onuoha, Ezenwa O. ; Bogdanovich, Tatiana ; Tian, Guo Bao ; Marschall, Jonas ; Urban, Carl M. ; Spellberg, Brad J. ; Rhee, Diane ; Halstead, Diane C. ; Pasculle, Anthony W. ; Doi, Yohei. / Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States. In: Journal of clinical microbiology. 2011 ; Vol. 49, No. 11. pp. 3849-3854.
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Adams-Haduch, JM, Onuoha, EO, Bogdanovich, T, Tian, GB, Marschall, J, Urban, CM, Spellberg, BJ, Rhee, D, Halstead, DC, Pasculle, AW & Doi, Y 2011, 'Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States', Journal of clinical microbiology, vol. 49, no. 11, pp. 3849-3854. https://doi.org/10.1128/JCM.00619-11

Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States. / Adams-Haduch, Jennifer M.; Onuoha, Ezenwa O.; Bogdanovich, Tatiana; Tian, Guo Bao; Marschall, Jonas; Urban, Carl M.; Spellberg, Brad J.; Rhee, Diane; Halstead, Diane C.; Pasculle, Anthony W.; Doi, Yohei.

In: Journal of clinical microbiology, Vol. 49, No. 11, 01.11.2011, p. 3849-3854.

Research output: Contribution to journalArticle

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Adams-Haduch JM, Onuoha EO, Bogdanovich T, Tian GB, Marschall J, Urban CM et al. Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States. Journal of clinical microbiology. 2011 Nov 1;49(11):3849-3854. https://doi.org/10.1128/JCM.00619-11