Molecular epidemiology of KPC-producing Escherichia coli

Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid

Jessica A. O'Hara, Fupin Hu, Chulsoo Ahn, Jeremy Nelson, Jesabel I. Rivera, Anthony W. Pasculle, Yohei Doi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.

Original languageEnglish
Pages (from-to)4234-4237
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number7
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

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Molecular Epidemiology
Klebsiella pneumoniae
Plasmids
Escherichia coli
Replicon
Sulfamethoxazole Drug Combination Trimethoprim
Gentamicins
carbapenemase

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

O'Hara, Jessica A. ; Hu, Fupin ; Ahn, Chulsoo ; Nelson, Jeremy ; Rivera, Jesabel I. ; Pasculle, Anthony W. ; Doi, Yohei. / Molecular epidemiology of KPC-producing Escherichia coli : Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid. In: Antimicrobial Agents and Chemotherapy. 2014 ; Vol. 58, No. 7. pp. 4234-4237.
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abstract = "Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60{\%} belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.",
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Molecular epidemiology of KPC-producing Escherichia coli : Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid. / O'Hara, Jessica A.; Hu, Fupin; Ahn, Chulsoo; Nelson, Jeremy; Rivera, Jesabel I.; Pasculle, Anthony W.; Doi, Yohei.

In: Antimicrobial Agents and Chemotherapy, Vol. 58, No. 7, 01.01.2014, p. 4234-4237.

Research output: Contribution to journalArticle

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