Molecular epidemiology of KPC-producing Escherichia coli: Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid

Jessica A. O'Hara; Fupin Hu; Chulsoo Ahn; Jeremy Nelson; Jesabel I. Rivera; Anthony W. Pasculle; Yohei Doi

doi:10.1128/AAC.02182-13

Molecular epidemiology of KPC-producing Escherichia coli: Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid

Jessica A. O'Hara
, Fupin Hu
, Chulsoo Ahn
, Jeremy Nelson
, Jesabel I. Rivera
, Anthony W. Pasculle
, Yohei Doi

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the bla_KPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three bla_KPC-carrying plasmids (IncA/C and IncN) possessed bla_SHV-7/12 and qnrA1 or qnrS1.

Original language	English
Pages (from-to)	4234-4237
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	7
DOIs	https://doi.org/10.1128/AAC.02182-13
Publication status	Published - 07-2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.02182-13

Cite this

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title = "Molecular epidemiology of KPC-producing Escherichia coli: Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid",

abstract = "Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60\% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.",

author = "O'Hara, \{Jessica A.\} and Fupin Hu and Chulsoo Ahn and Jeremy Nelson and Rivera, \{Jesabel I.\} and Pasculle, \{Anthony W.\} and Yohei Doi",

year = "2014",

month = jul,

doi = "10.1128/AAC.02182-13",

language = "English",

volume = "58",

pages = "4234--4237",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - Molecular epidemiology of KPC-producing Escherichia coli

T2 - Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid

AU - O'Hara, Jessica A.

AU - Hu, Fupin

AU - Ahn, Chulsoo

AU - Nelson, Jeremy

AU - Rivera, Jesabel I.

AU - Pasculle, Anthony W.

AU - Doi, Yohei

PY - 2014/7

Y1 - 2014/7

N2 - Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.

AB - Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.

UR - https://www.scopus.com/pages/publications/84903192771

UR - https://www.scopus.com/pages/publications/84903192771#tab=citedBy

U2 - 10.1128/AAC.02182-13

DO - 10.1128/AAC.02182-13

M3 - Article

C2 - 24820082

AN - SCOPUS:84903192771

SN - 0066-4804

VL - 58

SP - 4234

EP - 4237

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 7

ER -

Molecular epidemiology of KPC-producing Escherichia coli: Occurrence of ST131-fimH30 subclone harboring pKpQIL-like IncFIIk plasmid

Abstract

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