Molecular genetic study of schizophrenia based on neurodevelopmental hypothesis

Masashi Ikeda, Shinichiro Taya, Kozo Kaibuchi, Nakao Iwata, Norio Ozaki

Research output: Chapter in Book/Report/Conference proceedingChapter


The neurodevelopmental model of schizophrenia (1,2) is now a widely accepted hypothesis, and several investigations based on this model have been conducted. The actual pathophysiology of this disorder, however, is still not fully understood. The neurodevelopmental model suggests that schizophrenia is a behavioral phenotype, resulting from neurodevelopmental processes that start long before the onset of clinical manifestations and are due to a combination of environmental and genetic factors (Fig. 1). Clinical studies have provided the following support for this hypothesis (3).

Original languageEnglish
Title of host publicationNeurogenetics of Psychiatric Disorders
PublisherTaylor and Francis
Number of pages16
ISBN (Electronic)9781420019544
Publication statusPublished - 01-01-2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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