Molecular genetics of mood disorders

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Mood disorders are common diseases and cause a big burden on society, including suicide. Because there are many treatment-resistant cases in mood disorders, it is very important to elucidate the pathophysiology of this condition to establish its prevention and its treatment. Genetic epidemiological studies have shown that genetic factors have an important role in the pathophysiology of mood disorders; therefore the molecular genetics studies of this condition have been extensively performed, such as positional approach (i.e., linkage study) and candidate gene approach (i.e., association study). Linkage studies have shown some candidate locations that have been reproduced in two or more studies, such as 1q21-42, 4p16, 10q21-26, 11p15, 12q23-24, 13q11-32, 18p11, 18q21-22, 22q11-13, Xp11; and Xq24-28. Most association studies have until now focused on the neurotransmitter system as a candidate molecule including serotonin transporter, serotonin receptors, dopamine receptors, tyrosine hydroxylase, MAO-A, COMT, and tryptophan hydroxylase. Moreover, phamacogenetic studies also have been carried out in this field to develop new drugs as well as personalized medicine. Future molecular genetic studies will find out the mood-disorder susceptible genes and open the gate to true treatment and prevention of this disorder as the Human Genome Project attains its goal.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalJapanese Journal of Neuropsychopharmacology
Volume22
Issue number5
Publication statusPublished - 01-10-2002

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Inborn Genetic Diseases
Mood Disorders
Molecular Biology
Human Genome Project
Tryptophan Hydroxylase
Serotonin Plasma Membrane Transport Proteins
Precision Medicine
Serotonin Receptors
Monoamine Oxidase
Dopamine Receptors
Tyrosine 3-Monooxygenase
Suicide
Genes
Neurotransmitter Agents
Epidemiologic Studies
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

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title = "Molecular genetics of mood disorders",
abstract = "Mood disorders are common diseases and cause a big burden on society, including suicide. Because there are many treatment-resistant cases in mood disorders, it is very important to elucidate the pathophysiology of this condition to establish its prevention and its treatment. Genetic epidemiological studies have shown that genetic factors have an important role in the pathophysiology of mood disorders; therefore the molecular genetics studies of this condition have been extensively performed, such as positional approach (i.e., linkage study) and candidate gene approach (i.e., association study). Linkage studies have shown some candidate locations that have been reproduced in two or more studies, such as 1q21-42, 4p16, 10q21-26, 11p15, 12q23-24, 13q11-32, 18p11, 18q21-22, 22q11-13, Xp11; and Xq24-28. Most association studies have until now focused on the neurotransmitter system as a candidate molecule including serotonin transporter, serotonin receptors, dopamine receptors, tyrosine hydroxylase, MAO-A, COMT, and tryptophan hydroxylase. Moreover, phamacogenetic studies also have been carried out in this field to develop new drugs as well as personalized medicine. Future molecular genetic studies will find out the mood-disorder susceptible genes and open the gate to true treatment and prevention of this disorder as the Human Genome Project attains its goal.",
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Molecular genetics of mood disorders. / Ikeda, Masashi; Kitajima, Tsuyoshi; Iwata, Nakao; Ozaki, Norio.

In: Japanese Journal of Neuropsychopharmacology, Vol. 22, No. 5, 01.10.2002, p. 137-143.

Research output: Contribution to journalReview article

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AU - Iwata, Nakao

AU - Ozaki, Norio

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