Molecular mechanism of cholinergic dysfunction and cognitive deficits induced by amyloid β-peptide

M. H. Tran, K. Yamada, T. Nabeshima

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

Amyloid β-peptide (Aβ) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder; thus an insight into the cellular actions of Aβ and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of Aβ-induced brain dysfunction, especially cholinergic impairment and memory deficits, is summarized. Moreover, proposed mechanisms for Aβ-induced neurotoxicity such as oxidative stress, ion-channel formation, and Aβ-receptor interaction are discussed.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalJapanese Journal of Psychopharmacology
Volume21
Issue number4
Publication statusPublished - 29-12-2001

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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