TY - JOUR
T1 - Molecular mechanisms for nicotine intoxication
AU - Alkam, Tursun
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research C (grant number 24590219 , 26460240 , 15K08218 , 16K08421 ), B (grant number 17H04252 ) and the Private University Research Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Smoking Research Foundation Grant for Biomedical Research (SRF) .
PY - 2019/5
Y1 - 2019/5
N2 - Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.
AB - Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.
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U2 - 10.1016/j.neuint.2019.02.006
DO - 10.1016/j.neuint.2019.02.006
M3 - Review article
C2 - 30779928
AN - SCOPUS:85062206727
VL - 125
SP - 117
EP - 126
JO - Neurochemistry International
JF - Neurochemistry International
SN - 0197-0186
ER -