Abstract
Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 117-126 |
| Number of pages | 10 |
| Journal | Neurochemistry International |
| Volume | 125 |
| DOIs | |
| Publication status | Published - 01-05-2019 |
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All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Cell Biology
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Molecular mechanisms for nicotine intoxication. / Alkam, Tursun; Nabeshima, Toshitaka.
In: Neurochemistry International, Vol. 125, 01.05.2019, p. 117-126.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Molecular mechanisms for nicotine intoxication
AU - Alkam, Tursun
AU - Nabeshima, Toshitaka
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.
AB - Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.
UR - http://www.scopus.com/inward/record.url?scp=85062206727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062206727&partnerID=8YFLogxK
U2 - 10.1016/j.neuint.2019.02.006
DO - 10.1016/j.neuint.2019.02.006
M3 - Review article
C2 - 30779928
AN - SCOPUS:85062206727
VL - 125
SP - 117
EP - 126
JO - Neurochemistry International
JF - Neurochemistry International
SN - 0197-0186
ER -