Molecular mechanisms for nicotine intoxication

Tursun Alkam, Toshitaka Nabeshima

Research output: Contribution to journalReview article

Abstract

Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.

Original languageEnglish
Pages (from-to)117-126
Number of pages10
JournalNeurochemistry International
Volume125
DOIs
Publication statusPublished - 01-05-2019

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Nicotine
Tobacco
Agriculture
Sudden Infant Death
Peripheral Nervous System
Neurotoxins
Circadian Rhythm
Pesticides
Smoke
Central Nervous System
Pharmacokinetics
Eating
Newborn Infant

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

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abstract = "Nicotine, one of the more than 4700 ingredients in tobacco smoke, is a neurotoxin and once used as pesticides in agriculture. Although its use in agriculture is prohibited in many countries, nicotine intoxication is still a problem among the workers in tobacco farms, and young children as well as adults due to the accidental or suicidal ingestions of nicotine products. Understanding the mechanism of nicotine intoxication is important not only for the prevention and treatment but also for the appropriate regulatory approaches. Here, we review pharmacokinetics of nicotine and the molecular mechanisms for acute and chronic intoxication from nicotine that might be relevant to the central and the peripheral nervous system. We include green tobacco sickness, acute intoxication from popular nicotine products, circadian rhythm changes, chronic intoxication from nicotine through prenatal nicotine exposure, newborn behaviors, and sudden infant death syndrome.",
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Molecular mechanisms for nicotine intoxication. / Alkam, Tursun; Nabeshima, Toshitaka.

In: Neurochemistry International, Vol. 125, 01.05.2019, p. 117-126.

Research output: Contribution to journalReview article

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