Monitoring four herpesviruses in unrelated cord blood transplantation

N. Tanaka, H. Kimura, Y. Hoshino, K. Kato, Tetsushi Yoshikawa, Y. Asano, K. Horibe, S. Kojima, T. Morishima

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Cord blood transplantation, which has lower risk of graft-versus-host disease than bone marrow transplantation, might have higher risk of infections. A system to quantify four herpesviruses, CMV, human herpesvirus 6 (HHV6), EBV, varicella-zoster virus using the real-time PCR assay was established and applied for prospective viral load monitoring in three recipients undergoing cord blood transplantation. CMV and HHV6 were detected in peripheral blood from all three recipients, while EBV was detected in two. Varicellazoster virus was not detected at all. At the peak of HHV6 or CMV, each patient showed virus-related symptoms. During the pre-transplant period, CMV DNA was detected in two recipients who later developed CMV-related diseases. These observations indicate that our system is not only useful for managing herpesviruses infections in transplant recipients, but also a powerful method for clarifying the relationships between the viral load and clinical symptoms.

Original languageEnglish
Pages (from-to)1193-1197
Number of pages5
JournalBone Marrow Transplantation
Volume26
Issue number11
DOIs
Publication statusPublished - 01-01-2000

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Human Herpesvirus 6
Herpesviridae
Fetal Blood
Transplantation
Viral Load
Human Herpesvirus 4
Viruses
Herpesviridae Infections
Human Herpesvirus 3
Graft vs Host Disease
Bone Marrow Transplantation
Real-Time Polymerase Chain Reaction
Transplants
DNA
Infection

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Tanaka, N., Kimura, H., Hoshino, Y., Kato, K., Yoshikawa, T., Asano, Y., ... Morishima, T. (2000). Monitoring four herpesviruses in unrelated cord blood transplantation. Bone Marrow Transplantation, 26(11), 1193-1197. https://doi.org/10.1038/sj.bmt.1702710
Tanaka, N. ; Kimura, H. ; Hoshino, Y. ; Kato, K. ; Yoshikawa, Tetsushi ; Asano, Y. ; Horibe, K. ; Kojima, S. ; Morishima, T. / Monitoring four herpesviruses in unrelated cord blood transplantation. In: Bone Marrow Transplantation. 2000 ; Vol. 26, No. 11. pp. 1193-1197.
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Tanaka, N, Kimura, H, Hoshino, Y, Kato, K, Yoshikawa, T, Asano, Y, Horibe, K, Kojima, S & Morishima, T 2000, 'Monitoring four herpesviruses in unrelated cord blood transplantation', Bone Marrow Transplantation, vol. 26, no. 11, pp. 1193-1197. https://doi.org/10.1038/sj.bmt.1702710

Monitoring four herpesviruses in unrelated cord blood transplantation. / Tanaka, N.; Kimura, H.; Hoshino, Y.; Kato, K.; Yoshikawa, Tetsushi; Asano, Y.; Horibe, K.; Kojima, S.; Morishima, T.

In: Bone Marrow Transplantation, Vol. 26, No. 11, 01.01.2000, p. 1193-1197.

Research output: Contribution to journalArticle

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AU - Tanaka, N.

AU - Kimura, H.

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AU - Kato, K.

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AU - Horibe, K.

AU - Kojima, S.

AU - Morishima, T.

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AB - Cord blood transplantation, which has lower risk of graft-versus-host disease than bone marrow transplantation, might have higher risk of infections. A system to quantify four herpesviruses, CMV, human herpesvirus 6 (HHV6), EBV, varicella-zoster virus using the real-time PCR assay was established and applied for prospective viral load monitoring in three recipients undergoing cord blood transplantation. CMV and HHV6 were detected in peripheral blood from all three recipients, while EBV was detected in two. Varicellazoster virus was not detected at all. At the peak of HHV6 or CMV, each patient showed virus-related symptoms. During the pre-transplant period, CMV DNA was detected in two recipients who later developed CMV-related diseases. These observations indicate that our system is not only useful for managing herpesviruses infections in transplant recipients, but also a powerful method for clarifying the relationships between the viral load and clinical symptoms.

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