TY - JOUR
T1 - Morphine-Induced Straub Tail Reaction and Spinal Catecholamine Metabolite Content
T2 - Antagonism of Naloxone to Morphine-Induced Effects in Mice
AU - Kameyama, Tsutomu
AU - Nabeshima, Toshitaka
AU - Ukai, Makoto
AU - Yamaguchi, Kazumasa
PY - 1978
Y1 - 1978
N2 - The effects of morphine on the 3-methoxytyramine (3-MT) and normetanephrine (NM) level of various brain sites and two parts of spinal cord were investigated in mice with reference to our prior data on the effects of catecholaminergic agents on the morphine-induced Straub tail reaction (STR). Morphine (10 mg/kg) increased the 3-MT and NM content in the thoracic and lumbar regions of the spinal cord significantly, without affecting the 3-MT or NM content of the various brain sites. Naloxone (1 mg/kg) antagonized the morphine-induced increase in the 3-MT and NM in the thoracic and lumbar cord. These results suggest that morphine accelerates the release of spinal dopamine and norepinephrine. The morphine-induced STR might be due to the acceleration of catechol-aminergic neuronal activities in the spinal cord in mice.
AB - The effects of morphine on the 3-methoxytyramine (3-MT) and normetanephrine (NM) level of various brain sites and two parts of spinal cord were investigated in mice with reference to our prior data on the effects of catecholaminergic agents on the morphine-induced Straub tail reaction (STR). Morphine (10 mg/kg) increased the 3-MT and NM content in the thoracic and lumbar regions of the spinal cord significantly, without affecting the 3-MT or NM content of the various brain sites. Naloxone (1 mg/kg) antagonized the morphine-induced increase in the 3-MT and NM in the thoracic and lumbar cord. These results suggest that morphine accelerates the release of spinal dopamine and norepinephrine. The morphine-induced STR might be due to the acceleration of catechol-aminergic neuronal activities in the spinal cord in mice.
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U2 - 10.1248/cpb.26.2615
DO - 10.1248/cpb.26.2615
M3 - Article
C2 - 699205
AN - SCOPUS:0018186738
SN - 0009-2363
VL - 26
SP - 2615
EP - 2618
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 9
ER -