Morphological change in Pseudomonas aeruginosa following antibiotic treatment of experimental infection in mice and its relation to susceptibility to phagocytosis and to release of endotoxin

Takashi Yokochi, Kayou Narita, Akiko Morikawa, Kazuko Takahashi, Yutaka Kato, Tuyoshi Sugiyama, Naoki Koide, Makoto Kawai, Masako Fukada, Tomoaki Yoshida

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The relationship between morphological changes in Pseudomonas aeruginosa following antibiotic treatment of experimental infection in mice, susceptibility to phagocytosis, and release of endotoxin was studied. The intraperitoneal administration of P. aeruginosa with imipenem or ceftazidime into mice induced morphological changes in the cells 2 h after injection. Round P. aeruginosa cells with imipenem treatment became susceptible to phagocytosis by peritoneal cells, whereas long filamentous cells with ceftazidime treatment were hardly phagocytized by peritoneal cells. The morphological changes also affected the plasma endotoxin level in the circulation.

Original languageEnglish
Pages (from-to)205-206
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number1
DOIs
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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