TY - JOUR
T1 - Mouse model of relapse to the abuse of drugs
T2 - Procedural considerations and characterizations
AU - Yan, Yijin
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This study was supported in part by a Grant-in-aid for Health Science Research on Regulatory Science of Pharmaceuticals and Medical Devices, and for Research on Risk of Chemical Substances from the Ministry of Health, Labour and Welfare, Japan; by the Uehara Memorial Foundation; and by a Grant for the “Academic Frontier” Project for Private Universities (2007–2011) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2009/1/3
Y1 - 2009/1/3
N2 - To identify genetic risk factors involved in relapse to the abuse of drugs in humans, it is essential for researchers to develop a reliable mouse model of relapse by extending well-established extinction-reinstatement procedures in rats. Because of technical difficulties such as the relatively short duration of catheter patency in mice, few reports are available on the characterization of extinction-reinstatement behavior in wild-type and genetically engineered mutant mice. In this review, efforts are made to describe practical considerations during the establishment of extinction-reinstatement procedure in mice, including drug-primed, cue-induced, and stress-triggered reinstatement of previously extinguished drug-seeking behavior. Next, attention will be given to some characteristics of extinction-reinstatement behavior in mice. The present review might provide a new impetus in the exploration of genetic risk factors involved in relapse to drug dependence/addiction in humans using extinction-reinstatement procedures in widely available mutant mice.
AB - To identify genetic risk factors involved in relapse to the abuse of drugs in humans, it is essential for researchers to develop a reliable mouse model of relapse by extending well-established extinction-reinstatement procedures in rats. Because of technical difficulties such as the relatively short duration of catheter patency in mice, few reports are available on the characterization of extinction-reinstatement behavior in wild-type and genetically engineered mutant mice. In this review, efforts are made to describe practical considerations during the establishment of extinction-reinstatement procedure in mice, including drug-primed, cue-induced, and stress-triggered reinstatement of previously extinguished drug-seeking behavior. Next, attention will be given to some characteristics of extinction-reinstatement behavior in mice. The present review might provide a new impetus in the exploration of genetic risk factors involved in relapse to drug dependence/addiction in humans using extinction-reinstatement procedures in widely available mutant mice.
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U2 - 10.1016/j.bbr.2008.08.017
DO - 10.1016/j.bbr.2008.08.017
M3 - Review article
C2 - 18782591
AN - SCOPUS:56549109916
SN - 0166-4328
VL - 196
SP - 1
EP - 10
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -