Mouse model of relapse to the abuse of drugs: Procedural considerations and characterizations

Yijin Yan, Toshitaka Nabeshima

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


To identify genetic risk factors involved in relapse to the abuse of drugs in humans, it is essential for researchers to develop a reliable mouse model of relapse by extending well-established extinction-reinstatement procedures in rats. Because of technical difficulties such as the relatively short duration of catheter patency in mice, few reports are available on the characterization of extinction-reinstatement behavior in wild-type and genetically engineered mutant mice. In this review, efforts are made to describe practical considerations during the establishment of extinction-reinstatement procedure in mice, including drug-primed, cue-induced, and stress-triggered reinstatement of previously extinguished drug-seeking behavior. Next, attention will be given to some characteristics of extinction-reinstatement behavior in mice. The present review might provide a new impetus in the exploration of genetic risk factors involved in relapse to drug dependence/addiction in humans using extinction-reinstatement procedures in widely available mutant mice.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 03-01-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience


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