Mouse strain differences in phencyclidine-induced behavioural changes

Akihiro Mouri, Takenao Koseki, Shiho Narusawa, Minae Niwa, Takayoshi Mamiya, Shin Ichi Kano, Akira Sawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Administration of phencyclidine (PCP) is acknowledged to generate a model of psychosis in animals. With the identification of genetic susceptibility factors for schizophrenia and bipolar disorder, great efforts have been made to generate genetic animal models for major mental illnesses. As these disorders are multifactorial, comparisons among drug-induced (non-genetic) and genetic models are becoming an important issue in biological psychiatry. A major barrier is that the standard mouse strain used in the generation of genetic models is C57BL/6, whereas almost all studies with PCP-induced models have utilized other strains. To fill this technical gap, we systematically compared the behavioural changes upon PCP administration in different mouse strains, including C57BL/6N, C57BL/6J, ddY, and ICR. We observed strain differences in PCP-induced hyperlocomotion and enhanced immobility in the forced swim test (ddY>>C57BL/6N and 6J>ICR). In contrast, there was no strain difference in the impairment of recognition memory in the novel object recognition memory test after withdrawal of chronic PCP administration. This study provides practical guidance for comparing genetic with PCP-induced models of psychosis in C57BL/6. Furthermore, such strain differences may provide a clue to the biological mechanisms underlying PCP-induced endophenotypes possibly relevant to major mental illnesses.

Original languageEnglish
Pages (from-to)767-779
Number of pages13
JournalInternational Journal of Neuropsychopharmacology
Volume15
Issue number6
DOIs
Publication statusPublished - 01-07-2012
Externally publishedYes

Fingerprint

Phencyclidine
Genetic Models
Psychotic Disorders
Biological Psychiatry
Endophenotypes
Genetic Predisposition to Disease
Bipolar Disorder
Schizophrenia
Animal Models
Pharmaceutical Preparations
Recognition (Psychology)

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology
  • Psychiatry and Mental health

Cite this

Mouri, Akihiro ; Koseki, Takenao ; Narusawa, Shiho ; Niwa, Minae ; Mamiya, Takayoshi ; Kano, Shin Ichi ; Sawa, Akira ; Nabeshima, Toshitaka. / Mouse strain differences in phencyclidine-induced behavioural changes. In: International Journal of Neuropsychopharmacology. 2012 ; Vol. 15, No. 6. pp. 767-779.
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Mouse strain differences in phencyclidine-induced behavioural changes. / Mouri, Akihiro; Koseki, Takenao; Narusawa, Shiho; Niwa, Minae; Mamiya, Takayoshi; Kano, Shin Ichi; Sawa, Akira; Nabeshima, Toshitaka.

In: International Journal of Neuropsychopharmacology, Vol. 15, No. 6, 01.07.2012, p. 767-779.

Research output: Contribution to journalArticle

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