mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats

Miyuki Ota, Keiji Mori, Akira Nakashima, Yoko S. Kaneko, Goro Takami, Akira Ota

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study was undertaken to find an answer to the discrepancy between enhanced leptin mRNA expression level in white adipose tissue and its normal serum level in the rats given risperidone of 0.1 mg/kg/day (an equivalent dose to the standard one used for patients) for 21 consecutive days. In the white adipose tissues of rats injected with risperidone, mRNA expression levels of the genes encoding truncated a form of leptin receptor (Ob-Ra) and suppressor of cytokine signaling-3 (SOCS-3) were up-regulated; α1c-adrenergic receptor subtype mRNA expession level was down-regulated. On the contrary, the mRNA expression levels of the genes encoding long form of leptin receptor (Ob-Rb), Ob-Ra, SOCS-3, and neuropeptides known to regulate the appetite were not altered in the hypothalamus, a target site of leptin, obtained from the rats injected with risperidone for 21 consecutive days. These data indicate the importance of the adaptation that occurred in the white adipose tissue of the rats injected with risperidone for semi-chronic duration.

Original languageEnglish
Pages (from-to)299-308
Number of pages10
JournalBiogenic Amines
Volume19
Issue number4-6
DOIs
Publication statusPublished - 01-12-2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Pharmacology

Fingerprint Dive into the research topics of 'mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats'. Together they form a unique fingerprint.

  • Cite this