MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC Study

Asahi Hishida, Rieko Okada, Yin Guang, Mariko Naito, Kenji Wakai, Satoyo Hosono, Kazuyo Nakamura, Tanvir Chowdhury Turin, Sadao Suzuki, Hideshi Niimura, Haruo Mikami, Jun Otonari, Nagato Kuriyama, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. Methods: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. Results: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (<7.4 ng/ml) or high (≥7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Conclusions: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

Original languageEnglish
Pages (from-to)1613-1620
Number of pages8
JournalInternational Urology and Nephrology
Volume45
Issue number6
DOIs
Publication statusPublished - 01-12-2013

Fingerprint

Chronic Renal Insufficiency
Japan
Cohort Studies
Folic Acid
Odds Ratio
Genotype
Multiplex Polymerase Chain Reaction
Serum
Chronic Kidney Failure
Cardiovascular Diseases
Alleles

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Hishida, Asahi ; Okada, Rieko ; Guang, Yin ; Naito, Mariko ; Wakai, Kenji ; Hosono, Satoyo ; Nakamura, Kazuyo ; Turin, Tanvir Chowdhury ; Suzuki, Sadao ; Niimura, Hideshi ; Mikami, Haruo ; Otonari, Jun ; Kuriyama, Nagato ; Katsuura, Sakurako ; Kubo, Michiaki ; Tanaka, Hideo ; Hamajima, Nobuyuki. / MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese : Cross-sectional data from the J-MICC Study. In: International Urology and Nephrology. 2013 ; Vol. 45, No. 6. pp. 1613-1620.
@article{2ea2c08a225043b284eedcb923cb33ec,
title = "MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC Study",
abstract = "Purpose: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. Methods: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. Results: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 {\%} CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (<7.4 ng/ml) or high (≥7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 {\%} CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Conclusions: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.",
author = "Asahi Hishida and Rieko Okada and Yin Guang and Mariko Naito and Kenji Wakai and Satoyo Hosono and Kazuyo Nakamura and Turin, {Tanvir Chowdhury} and Sadao Suzuki and Hideshi Niimura and Haruo Mikami and Jun Otonari and Nagato Kuriyama and Sakurako Katsuura and Michiaki Kubo and Hideo Tanaka and Nobuyuki Hamajima",
year = "2013",
month = "12",
day = "1",
doi = "10.1007/s11255-013-0432-0",
language = "English",
volume = "45",
pages = "1613--1620",
journal = "International Urology and Nephrology",
issn = "0301-1623",
publisher = "Springer Netherlands",
number = "6",

}

Hishida, A, Okada, R, Guang, Y, Naito, M, Wakai, K, Hosono, S, Nakamura, K, Turin, TC, Suzuki, S, Niimura, H, Mikami, H, Otonari, J, Kuriyama, N, Katsuura, S, Kubo, M, Tanaka, H & Hamajima, N 2013, 'MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC Study', International Urology and Nephrology, vol. 45, no. 6, pp. 1613-1620. https://doi.org/10.1007/s11255-013-0432-0

MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese : Cross-sectional data from the J-MICC Study. / Hishida, Asahi; Okada, Rieko; Guang, Yin; Naito, Mariko; Wakai, Kenji; Hosono, Satoyo; Nakamura, Kazuyo; Turin, Tanvir Chowdhury; Suzuki, Sadao; Niimura, Hideshi; Mikami, Haruo; Otonari, Jun; Kuriyama, Nagato; Katsuura, Sakurako; Kubo, Michiaki; Tanaka, Hideo; Hamajima, Nobuyuki.

In: International Urology and Nephrology, Vol. 45, No. 6, 01.12.2013, p. 1613-1620.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese

T2 - Cross-sectional data from the J-MICC Study

AU - Hishida, Asahi

AU - Okada, Rieko

AU - Guang, Yin

AU - Naito, Mariko

AU - Wakai, Kenji

AU - Hosono, Satoyo

AU - Nakamura, Kazuyo

AU - Turin, Tanvir Chowdhury

AU - Suzuki, Sadao

AU - Niimura, Hideshi

AU - Mikami, Haruo

AU - Otonari, Jun

AU - Kuriyama, Nagato

AU - Katsuura, Sakurako

AU - Kubo, Michiaki

AU - Tanaka, Hideo

AU - Hamajima, Nobuyuki

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Purpose: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. Methods: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. Results: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (<7.4 ng/ml) or high (≥7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Conclusions: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

AB - Purpose: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. Methods: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. Results: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (<7.4 ng/ml) or high (≥7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Conclusions: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

UR - http://www.scopus.com/inward/record.url?scp=84890803951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890803951&partnerID=8YFLogxK

U2 - 10.1007/s11255-013-0432-0

DO - 10.1007/s11255-013-0432-0

M3 - Article

C2 - 23595572

AN - SCOPUS:84890803951

VL - 45

SP - 1613

EP - 1620

JO - International Urology and Nephrology

JF - International Urology and Nephrology

SN - 0301-1623

IS - 6

ER -