Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model

Hideaki Wakita, Christl Ruetzler, Kachikwu O. Illoh, Yong Chen, Asako Takanohashi, Maria Spatz, John M. Hallenbeck

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Vascular cognitive impairment (VCI) is the second most prevalent type of dementia in the world. The white matter damage that characterizes the common subcortical ischemic form of VCI can be modeled by ligating both common carotid arteries in the Wistar rat to induce protracted cerebral hypoperfusion. In this model, we find that repetitive intranasal administration of recombinant E-selectin to induce mucosal tolerance and to target immunomodulation to activating blood vessels potently suppresses both white matter (and possibly gray matter) damage and markers of vessel activation (tumor necrosis factor and E-selectin); it also preserves behavioral function in T-maze spontaneous alternation, T-maze spatial discrimination memory retention, and object recognition tests. Immunomodulation may be an effective novel strategy to prevent progression of VCI.

Original languageEnglish
Pages (from-to)341-353
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume28
Issue number2
DOIs
Publication statusPublished - 01-02-2008

Fingerprint

E-Selectin
Blood Vessels
Immunomodulation
Intranasal Administration
Common Carotid Artery
Dementia
Wistar Rats
Tumor Necrosis Factor-alpha
Cognitive Dysfunction
White Matter

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Wakita, Hideaki ; Ruetzler, Christl ; Illoh, Kachikwu O. ; Chen, Yong ; Takanohashi, Asako ; Spatz, Maria ; Hallenbeck, John M. / Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model. In: Journal of Cerebral Blood Flow and Metabolism. 2008 ; Vol. 28, No. 2. pp. 341-353.
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Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model. / Wakita, Hideaki; Ruetzler, Christl; Illoh, Kachikwu O.; Chen, Yong; Takanohashi, Asako; Spatz, Maria; Hallenbeck, John M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 28, No. 2, 01.02.2008, p. 341-353.

Research output: Contribution to journalArticle

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