Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Australian Asthma Genetics Consortium (AAGCGC), EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

Original languageEnglish
Pages (from-to)1449-1456
Number of pages8
JournalNature Genetics
Volume47
Issue number12
DOIs
Publication statusPublished - 01-12-2015

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Genome-Wide Association Study
Atopic Dermatitis
Genetic Association Studies
Hispanic Americans
Skin Diseases
Population
Meta-Analysis
T-Lymphocytes
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Australian Asthma Genetics Consortium (AAGCGC), & EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47(12), 1449-1456. https://doi.org/10.1038/ng.3424
Australian Asthma Genetics Consortium (AAGCGC) ; EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium. / Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. In: Nature Genetics. 2015 ; Vol. 47, No. 12. pp. 1449-1456.
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abstract = "Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.",
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Australian Asthma Genetics Consortium (AAGCGC) & EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium 2015, 'Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis', Nature Genetics, vol. 47, no. 12, pp. 1449-1456. https://doi.org/10.1038/ng.3424

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. / Australian Asthma Genetics Consortium (AAGCGC); EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium.

In: Nature Genetics, Vol. 47, No. 12, 01.12.2015, p. 1449-1456.

Research output: Contribution to journalArticle

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AU - EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium

AU - Paternoster, Lavinia

AU - Standl, Marie

AU - Waage, Johannes

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AU - Curtin, John A.

AU - Bønnelykke, Klaus

AU - Tian, Chao

AU - Takahashi, Atsushi

AU - Esparza-Gordillo, Jorge

AU - Alves, Alexessander Couto

AU - Thyssen, Jacob P.

AU - Den Dekker, Herman T.

AU - Ferreira, Manuel A.

AU - Altmaier, Elisabeth

AU - Sleiman, Patrick M.A.

AU - Xiao, Feng Li

AU - Gonzalez, Juan R.

AU - Marenholz, Ingo

AU - Kalb, Birgit

AU - Pino-Yanes, Maria

AU - Xu, Cheng Jian

AU - Carstensen, Lisbeth

AU - Groen-Blokhuis, Maria M.

AU - Venturini, Cristina

AU - Pennell, Craig E.

AU - Barton, Sheila J.

AU - Levin, Albert M.

AU - Curjuric, Ivan

AU - Bustamante, Mariona

AU - Kreiner-Møller, Eskil

AU - Lockett, Gabrielle A.

AU - Bacelis, Jonas

AU - Bunyavanich, Supinda

AU - Myers, Rachel A.

AU - Matanovic, Anja

AU - Kumar, Ashish

AU - Tung, Joyce Y.

AU - Hirota, Tomomitsu

AU - Kubo, Michiaki

AU - McArdle, Wendy L.

AU - Henderson, A. John

AU - Kemp, John P.

AU - Zheng, Jie

AU - Smith, George Davey

AU - Rüschendorf, Franz

AU - Bauerfeind, Anja

AU - Lee-Kirsch, Min Ae

AU - Kubo, Michiaki

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Australian Asthma Genetics Consortium (AAGCGC), EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics. 2015 Dec 1;47(12):1449-1456. https://doi.org/10.1038/ng.3424