Multicenter 1-month follow-up study of the patch test reaction to the gold sodium thiosulfate of the TRUE Test and its association with piercings and dental metal history

Kayoko Suzuki, Kayoko Matsunaga, Akiko Ito, Akiko Yagami, Takashi Ito, Hitoshi Miyazawa, Mariko Sugiura, Atsuko Adachi, Yumiko Kubota, Yuko Watanabe, Atsuko Kato, Kazue Nishioka, Atsushi Fukunaga, Masako Mochizuki, Yuko Ikezawa, Takahiko Tsunoda, Kaoru Takayama, Kumiko Washizaki, Hiroo Yokozeki, Takuma IshiharaHideo Asada, Hiromi Kanto

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is controversy over late and long-lasting reactions to gold sodium thiosulfate (GST). Objectives: To study the GST patch test reaction by observing the application site after 1 month, and to clarify the relevance of GST sensitization by piercings and dental metals. Patients: A retrospective analysis was performed on 746 patients (143 male; 603 female) who were patch tested using GST of the TRUE Test. We conducted a questionnaire on the presence of piercings or dental metals in these patients. Results: The GST positive rate was 27.9% at day (D)3 and/or D7 and 40.3% up to the 1-month reading. The positive rate was significantly higher in female patients and increased with age. Sixty-two percent of cases with a positive reaction at D7 continued to show a positive reaction after 1 month. Eleven percent of cases with a negative reaction at D3 and D7 showed a late reaction. Both piercings and dental metals were related to gold sensitization. Conclusions: The GST of the TRUE Test had a high positive and low false-negative rate. The 1-month reading after the patch test was important for identifying late reactions. Piercing history and dental metal were associated with gold sensitization.

Original languageEnglish
Pages (from-to)154-163
Number of pages10
JournalContact Dermatitis
Volume85
Issue number2
DOIs
Publication statusPublished - 08-2021

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

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